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Machine perfusion ameliorates nonanastomotic strictures after liver transplantation: a systematic review and meta-analysis of randomized controlled trials

INTRODUCTION:  - Machine perfusion (MP) technology may reduce the incidence of biliary complications (BCs) by reducing ischemia-reperfusion injury. This meta-analysis aimed to compare the effects of MP and static cold storage (SCS) on the incidence of BCs, nonanastomotic stricture (NAS), and anasto...

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Main Authors: Wang, Xi (Author) , Yin, Xiubi (Author) , Gao, Yu-Geng (Author) , Liu, Wei (Author) , Jiang, Di (Author) , Zhang, Leida (Author) , Zhang, Chengcheng (Author)
Format: Article (Journal)
Language:English
Published: March 2026
In: Clinical and translational gastroenterology
Year: 2026, Volume: 17, Issue: 3, Pages: 1-9
ISSN:2155-384X
DOI:10.14309/ctg.0000000000000978
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.14309/ctg.0000000000000978
Verlag, kostenfrei, Volltext: https://journals.lww.com/ctg/fulltext/2026/03000/machine_perfusion_ameliorates_nonanastomotic.2.aspx
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Author Notes:Xi Wang, MD, Xiubi Yin, MD, Yugeng Gao, MD, Wei Liu, MD, Di Jiang, MD, Leida Zhang, MD and Chengcheng Zhang, MD
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Summary:INTRODUCTION:  - Machine perfusion (MP) technology may reduce the incidence of biliary complications (BCs) by reducing ischemia-reperfusion injury. This meta-analysis aimed to compare the effects of MP and static cold storage (SCS) on the incidence of BCs, nonanastomotic stricture (NAS), and anastomotic stricture (AS) after liver transplantation. - METHODS:  - Randomized controlled trials (RCTs) comparing the effects of MP versus SCS on BCs, NAS, or AS after liver transplantation were included for the systematic review in October 2024. Random-effects models were used to perform pooled analyses to calculate risk ratios (RRs) with 95% confidence intervals (CIs). - RESULTS:  - A total of 9 RCTs including 6 hypothermic oxygenate perfusion (HOPE) and 3 normothermic MP (NMP) were eligible for inclusion. Compared with SCS, MP technology seemed to reduce the incidence of BCs (HOPE: RR 0.77, 95% CI 0.62-0.97, P = 0.03; NMP: RR 0.67, 95% CI 0.44-1.00, P = 0.05). In addition, MP technology could explicitly reduce NAS incidence (HOPE: RR 0.40, 95% CI 0.19-0.84, P = 0.01; NMP: RR 0.39, 95% CI 0.19-0.83, P = 0.01). However, MP technology was likely unable to reduce the incidence of AS (HOPE: RR 0.89, 95% CI 0.63-1.26, P = 0.51; NMP: RR 0.99, 95% CI 0.53-1.85, P = 0.99). - DISCUSSION:  - This meta-analysis confirmed that MP technology could reduce the incidence of NAS, which might further lead to a reduction in the incidence of BCs. However, it did not seem to improve AS incidence.
Item Description:Online veröffentlicht: 28. Januar 2026
Gesehen am 27.04.2026
Physical Description:Online Resource
ISSN:2155-384X
DOI:10.14309/ctg.0000000000000978

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