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Identification of serum biomarkers linking myocardial fibrosis, systolic dysfunction and outcomes in patients with severe aortic stenosis: research letter

Time of primary review: 57 daysDear Editor,aortic valve stenosis (AS) is the most prevalent acquired heart valve disease in the Western world, affecting over 2% of individuals over the age of 60 and imposing a significant burden of morbidity and mortality.1 Transcatheter aortic valve replacement (TA...

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Autori principali: Gersch, Svante Sören (Autore) , Ferreira, João P (Autore) , Leha, Andreas (Autore) , Bengel, Philipp (Autore) , von Haehling, Stephan (Autore) , Fischer, Andreas (Autore) , Beuthner, Bo E (Autore) , Zeisberg, Elisabeth M (Autore) , Puls, Miriam (Autore) , Schmidt, Constanze (Autore) , Toischer, Karl (Autore) , Hasenfuß, Gerd (Autore) , Schnelle, Moritz (Autore)
Natura: Article (Journal) Editorial
Lingua:inglese
Pubblicazione: 30 March 2026
In: Cardiovascular research
Year: 2026, Pages: 1-4
ISSN:1755-3245
DOI:10.1093/cvr/cvag073
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/cvr/cvag073
Testo
Note sull'autore:Svante Gersch, João P. Ferreira, Andreas Leha, Philipp Bengel, Stephan von Haehling, Andreas Fischer, Bo E. Beuthner, Elisabeth M. Zeisberg, Miriam Puls, Constanze Schmidt, Karl Toischer, Gerd Hasenfuß, and Moritz Schnelle
Descrizione
Riassunto:Time of primary review: 57 daysDear Editor,aortic valve stenosis (AS) is the most prevalent acquired heart valve disease in the Western world, affecting over 2% of individuals over the age of 60 and imposing a significant burden of morbidity and mortality.1 Transcatheter aortic valve replacement (TAVR) has become the preferred choice of intervention in the management of aortic valve disease, with a notable increase in the number of procedures performed over the last years due to an aging society.2 Consequently, effective risk stratification becomes essential for selecting suitable candidates and improving outcomes in severe AS. Pathophysiologically, the progression of AS affects the left ventricle, leading to myocardial adaptations such as cardiac hypertrophy and diffuse myocardial fibrosis (MF).3 Emerging evidence suggests a link between the degree of MF and impaired outcomes after AVR in severe AS patients.4 While cardiac biopsy remains the most reliable method for measuring MF, it is an invasive procedure that poses significant risks of severe complications. Therefore, there is a pressing need for simpler methods to assess MF levels.5 Approaches to non-invasively identify serum biomarkers to estimate the degree of MF in patients with AS remain scarce.5 To address this issue, we conducted a comprehensive proteomic analysis, utilizing a large panel of serum biomarkers. Specifically, we analyzed 184 biomarkers using the Olink® technology (CVDII and CVDIII panels; Olink®, Uppsala, Sweden) in 169 serum samples from our well-characterized TAVR cohort,4 collected prior to the procedure, and examined their associations with histologically assessed MF, systolic dysfunction and cardiovascular mortality.
Descrizione del documento:Gesehen am 27.04.2026
Descrizione fisica:Online Resource
ISSN:1755-3245
DOI:10.1093/cvr/cvag073

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