High procalcitonin in Gram-negative urosepsis: indicator of immune modulation rather than poor outcome
Procalcitonin (PCT) is an acute-phase protein and widely used marker for diagnosing bacterial infection and sepsis, but its physiological role remains incompletely defined. Interleukin-1β (IL-1β) is a critical mediator of the immune response to infection, whose excessive release can drive remote org...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
27 February 2026
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| In: |
World journal of urology
Year: 2026, Volume: 44, Pages: 1-9 |
| ISSN: | 1433-8726 |
| DOI: | 10.1007/s00345-026-06199-2 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00345-026-06199-2
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| Author Notes: | Sebastian Petzoldt, Christina Buschhaus, Matthias Hecker, Arne Hauptmann, Florian Wagenlehner, Matthias Wolff, Martin Reichert, Veronika Grau, Andreas Hecker, Markus Weigand, Anca-Laura Amati |
| Summary: | Procalcitonin (PCT) is an acute-phase protein and widely used marker for diagnosing bacterial infection and sepsis, but its physiological role remains incompletely defined. Interleukin-1β (IL-1β) is a critical mediator of the immune response to infection, whose excessive release can drive remote organ injury and dysfunction. Its secretion is therefore tightly controlled. Because other acute-phase proteins have been shown to regulate IL-1β secretion, we investigated whether PCT exerts a similar immunomodulatory effect and whether this influences sepsis severity, particularly in Gram-negative urosepsis. |
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| Item Description: | Gesehen am 04.05.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1433-8726 |
| DOI: | 10.1007/s00345-026-06199-2 |