Patterns, risk factors and management of CD19-directed chimeric antigen receptor T-cell therapy failure in CNS lymphoma

CD19-directed chimeric antigen receptor T-cell therapy (CD19-CAR) has yielded encouraging efficacy in CNS lymphomas (CNSL), but most patients ultimately experience progressive disease (PD). Risk factors, progression patterns as well as optimal salvage therapies remain unclear.

Bibliographic Details

Main Authors:	Kaulen, Leon D. (Author) , Karschnia, Philipp (Author) , Doubrovinskaia, Sofia (Author) , Abramson, Jeremy S. (Author) , Soumerai, Jacob D. (Author) , Martinez-Lage, Maria (Author) , Haydu, J. Erika (Author) , Shankar, Ganesh M. (Author) , Patel, Chirayu (Author) , Choi, Bryan D. (Author) , Barnes, Jeffrey A. (Author) , El-Jawahri, Areej (Author) , Hochberg, Ephraim P. (Author) , Johnson, P. Connor (Author) , Wick, Wolfgang (Author) , Maus, Marcela V. (Author) , Chen, Yi-Bin (Author) , Frigault, Matthew J. (Author) , Dietrich, Jorg (Author)
Format:	Article (Journal)
Language:	English
Published:	14 January 2026
In:	Journal of hematology & oncology Year: 2026, Volume: 19, Issue: 1, Pages: 1-7
ISSN:	1756-8722
DOI:	10.1186/s13045-025-01761-8
Online Access:	Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13045-025-01761-8 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s13045-025-01761-8?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate
Author Notes:	Leon D. Kaulen, Philipp Karschnia, Sofia Doubrovinskaia, Jeremy S. Abramson, Jacob D. Soumerai, Maria Martinez-Lage, J. Erika Haydu, Ganesh M. Shankar, Chirayu Patel, Bryan D. Choi, Jeffrey A. Barnes, Areej El-Jawahri, Ephraim P. Hochberg, P. Connor Johnson, Wolfgang Wick, Marcela V. Maus, Yi-Bin Chen, Matthew J. Frigault and Jorg Dietrich