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MER57E3 transposable elements regulate gene expression in a human cell model of neural development

Long dismissed as mere genomic parasites, transposable elements (TEs) are now recognized as major drivers of genome evolution. TEs serve as a source of cell-type specific cis-regulatory elements, influencing gene expression and observable phenotypes. However, the precise TE regulatory roles in diffe...

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Autori principali: Almeida da Paz, Michelle (Autore) , Yildiz, Umut (Autore) , Kim, Minyoung (Autore) , Campos Fornés, Víctor (Autore) , Pinkasz, Marina (Autore) , Dahlet, Thomas (Autore) , Noh, Kyung-Min (Autore) , Taher, Leila (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 31 January 2026
In: Genome biology
Year: 2026, Volume: 27, Pages: 1-26
ISSN:1474-760X
DOI:10.1186/s13059-026-03946-x
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13059-026-03946-x
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Note sull'autore:Michelle Almeida da Paz, Umut Yildiz, Minyoung Kim, Víctor Campos-Fornés, Marina Pinkasz, Thomas Dahlet, Kyung-Min Noh and Leila Taher
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Riassunto:Long dismissed as mere genomic parasites, transposable elements (TEs) are now recognized as major drivers of genome evolution. TEs serve as a source of cell-type specific cis-regulatory elements, influencing gene expression and observable phenotypes. However, the precise TE regulatory roles in different contexts remain largely unexplored and the impact of TEs on transcriptional regulatory networks and contribution to disease risk is likely deeply underestimated.
Descrizione del documento:Gesehen am 07.05.2026
Descrizione fisica:Online Resource
ISSN:1474-760X
DOI:10.1186/s13059-026-03946-x

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