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Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone

Glioblastoma (GB) cells infiltrate the brain parenchyma and colonize distant regions, driving recurrence and therapy resistance. Here, we examined dynamic microglial responses to infiltrating tumor cells during GB progression. Three-photon imaging in an autochthonous, immunocompetent GB mouse model...

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Autori principali: Nebeling, Felix Christopher (Autore) , Fuhrmann, Falko (Autore) , Mittag, Manuel (Autore) , Musacchio, Fabrizio (Autore) , Antony, Henrike (Autore) , Gockel, Nala (Autore) , Friker, Lea L. (Autore) , Leonardelli, Sonia (Autore) , Filser, Severin (Autore) , A., Deli (Autore) , Stork, Miriam (Autore) , Bano, Daniele (Autore) , Pietsch, Torsten (Autore) , Giordano, Frank Anton (Autore) , Zhou, Qihui (Autore) , Parrinello, Simona (Autore) , Hölzel, Michael (Autore) , Herrlinger, Ulrich (Autore) , Salomoni, Paolo (Autore) , Fuhrmann, Martin (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 14 April 2026
In: Immunity
Year: 2026, Volume: 59, Fascicolo: 4, Pages: 1075-1091,1-4
ISSN:1097-4180
DOI:10.1016/j.immuni.2026.03.010
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.immuni.2026.03.010
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1074761326001214
Testo
Note sull'autore:Felix C. Nebeling, Falko Fuhrmann, Manuel Mittag, Fabrizio Musacchio, Henrike Antony, Nala Gockel, Lea L. Friker, Sonia Leonardelli, Severin Filser, Deli A., Miriam Stork, Daniele Bano, Torsten Pietsch, Frank A. Giordano, Qihui Zhou, Simona Parrinello, Michael Hölzel, Ulrich Herrlinger, Paolo Salomoni, and Martin Fuhrmann
Descrizione
Riassunto:Glioblastoma (GB) cells infiltrate the brain parenchyma and colonize distant regions, driving recurrence and therapy resistance. Here, we examined dynamic microglial responses to infiltrating tumor cells during GB progression. Three-photon imaging in an autochthonous, immunocompetent GB mouse model enabled visualization of microglia-GB interactions at the far infiltration zone (FIZ) in the corpus callosum (CC). GB infiltration speed varied by anatomical location and tumor microtube (TM) number. Microglia increased surveillance in sparsely infiltrated areas but reduced it with higher GB density, revealing a biphasic response. Directional migration toward GB cells was restricted to microglial subsets within a defined spatial range, indicating heterogeneous reactivity. CX3CR1 deficiency enhanced microglial reactivity while limiting GB cell migration. Microglia depletion with the CSF1R inhibitor PLX5622 reduced GB cell migration and constrained TM plasticity. Thus, microglia respond to GB cell infiltration in a stage-dependent manner and critically modulate dissemination at the FIZ.
Descrizione del documento:Gesehen am 19.05.2026
Descrizione fisica:Online Resource
ISSN:1097-4180
DOI:10.1016/j.immuni.2026.03.010

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