Prognostic relevance of MIB-1 labeling index in VHL-associated and sporadic spinal hemangioblastomas: a subgroup analysis from a multicentric study
Spinal hemangioblastomas (sHB) are rare vascular tumors, with distinct clinical courses between von Hippel-Lindau (VHL)-associated and sporadic cases. The MIB-1 labeling index has been proposed as a surrogate marker for tumor proliferation, but its prognostic value remains unclear in this context. I...
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
11 December 2025
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| In: |
Acta Neuropathologica Communications
Year: 2025, Volumen: 14, Pages: 1-10 |
| ISSN: | 2051-5960 |
| DOI: | 10.1186/s40478-025-02202-w |
| Acceso en línea: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s40478-025-02202-w Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s40478-025-02202-w 
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| Notas de Autor: | Johannes Wach, Alim Emre Basaran, Obada T. Alhalabi, Jürgen Beck, Vicki M. Butenschoen, Steven D. Chang, Marcus Czabanka, Tomasz Czernicki, Philipp Dammann, Roberto Doria-Medina, Sven Oliver Eicker, Alonso Barrantes-Freer, Christine Gizaw, Erdem Güresir, Marc Hohenhaus, Romina Hohenhaus, Ahed H. Kattaa, Fatma Kilinc, Lukas Klein, Nikolaus Kögl, Sandro Krieg, Przemyslaw Kunert, Maximilian Middelkamp, Bernhard Meyer, Nicolas Neidert, Julia Onken, Tobias Pantel, David J. Park, Laurèl Rauschenbach, Roman Sankowski, Alejandro N. Santos, Nils Ole Schmidt, Sebastian Siller, Ulrich Sure, Claudius Thomé, Tarik Tihan, Martin Vychopen, Peter Vajkoczy, Maria Wostrack and Jan-Helge Klingler |
| Sumario: | Spinal hemangioblastomas (sHB) are rare vascular tumors, with distinct clinical courses between von Hippel-Lindau (VHL)-associated and sporadic cases. The MIB-1 labeling index has been proposed as a surrogate marker for tumor proliferation, but its prognostic value remains unclear in this context. In this subgroup analysis from a multicenter retrospective study, we analyzed 116 primary sHB patients with available MIB-1 indices. Patients were stratified by VHL status. Statistical comparisons included ROC analyses for local progression-free survival (PFS) prediction and Kaplan-Meier survival curves for local PFS, stratified by a MIB-1 index cut-off derived from Youden’s index. The MIB-1 index was significantly lower in VHL-associated tumors compared to sporadic ones (mean 2.17% vs. 3.02%, p = 0.008). In VHL-associated sHB, a higher MIB-1 index (≥ 2%) correlated with an increased risk of local tumor progression (AUC 0.74, 95% CI 0.49-0.98), whereas this was not observed in sporadic cases (AUC 0.56, 95% CI 0.23-0.88). Kaplan-Meier analysis showed that VHL patients with MIB-1 ≥ 2% had significantly shorter PFS (p = 0.05), while no significant association was found in sporadic tumors (p = 0.87). Our findings suggest that while VHL-associated sHB exhibit lower proliferative indices overall, elevated MIB-1 labeling indices might serve as a prognostic marker of shorter local PFS in this subgroup. In contrast, MIB-1 index appears to have limited prognostic relevance in sporadic sHB. These results highlight the importance of further molecular stratification and proliferation assessment in sHB to better inform clinical decision-making. |
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| Notas: | Artikelversion: 14. Januar 2026 Gesehen am 19.05.2026 |
| Descripción Física: | Online Resource |
| ISSN: | 2051-5960 |
| DOI: | 10.1186/s40478-025-02202-w |