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Cancer neuroscience: The past, the present, and the road ahead

Both the nervous system and cancer-intrinsic neural features can govern cancer initiation, growth, progression, metastasis, and treatment resistance, while cancer can likewise influence the nervous system, promoting neural reprogramming and neuropsychiatric symptoms that worsen patient outcomes. The...

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Autores principales: Winkler, Frank (Autor) , Heuer, Sophie (Autor) , Althammer, Ferdinand (Autor) , Augustin, Hellmut (Autor) , Beleggia, Filippo (Autor) , Demir, Ihsan Ekin (Autor) , Koenig, Julian (Autor) , Kuner, Rohini (Autor) , Kuner, Thomas (Autor) , Loges, Sonja (Autor) , Platten, Michael (Autor) , Reinhardt, Christian (Autor) , Rich, Judith M. (Autor) , Sahm, Felix (Autor) , Stassart, Ruth Martha (Autor) , Thiel, Vera (Autor) , Trumpp, Andreas (Autor) , Venkataramani, Varun (Autor) , Wick, Wolfgang (Autor) , Karreman, Matthia A. (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: April 16, 2026
In: Cell
Year: 2026, Volumen: 189, Número: 8, Pages: 2464-2489
ISSN:1097-4172
DOI:10.1016/j.cell.2026.03.018
Acceso en línea:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.cell.2026.03.018
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0092867426002850
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Notas de Autor:Frank Winkler, Sophie Heuer, Ferdinand Althammer, Hellmut Augustin, Filippo Beleggia, Ihsan Ekin Demir, Julian Koenig, Rohini Kuner, Thomas Kuner, Sonja Loges, Michael Platten, Hans Christian Reinhardt, Judith M. Rich, Felix Sahm, Ruth Martha Stassart, Vera Thiel, Andreas Trumpp, Varun Venkataramani, Wolfgang Wick, and Matthia A. Karreman
Descripción
Sumario:Both the nervous system and cancer-intrinsic neural features can govern cancer initiation, growth, progression, metastasis, and treatment resistance, while cancer can likewise influence the nervous system, promoting neural reprogramming and neuropsychiatric symptoms that worsen patient outcomes. The field of cancer neuroscience seeks to unravel this complex neuro-cancer crosstalk and holds the promise to develop neuroscience-instructed cancer therapies that improve disease control and quality of life. Here, we summarize the key discoveries of neuro-cancer crosstalk to date, including neuron-to-cancer synapses and paracrine and neuro-immuno-oncological interactions, and then explore emerging topics such as downstream effects on cancer cell pathophysiology, circadian influences, brain-body-cancer communication, and neural regulation of the metastatic cascade and the tumor microenvironment. Finally, we distill overarching principles, highlight relevant ongoing research, and outline conclusions to guide the development of cancer neuroscience, proposing hypotheses for future experimental validation.
Notas:Online verfügbar: 16. April 2026, Artikelversion: 16. April 2026
Gesehen am 21.05.2026
Descripción Física:Online Resource
ISSN:1097-4172
DOI:10.1016/j.cell.2026.03.018

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