Buchumschlag

Updated recommendations for pediatric surveillance in hereditary endocrine neoplasia syndromes: multiple endocrine neoplasias, hyperparathyroidism-jaw tumor syndrome, and Carney Complex

Hereditary endocrine neoplasia syndromes comprise multiple entities associated with an increased risk for the development of endocrine and nonendocrine neoplasms and other systemic manifestations. These syndromes typically demonstrate autosomal dominant inheritance, and each syndrome is associated w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Wasserman, Jonathan (Verfasst von) , Schneider, Kami Wolfe (Verfasst von) , Achatz, Maria Isabel (Verfasst von) , Nakano, Yoshiko (Verfasst von) , Zelley, Kristin (Verfasst von) , Gallinger, Bailey (Verfasst von) , Bauer, Andrew J. (Verfasst von) , Becktell, Kerri D. (Verfasst von) , Wassner, Ari J. (Verfasst von) , Raiti, Laura (Verfasst von) , Doria, Andrea S. (Verfasst von) , States, Lisa J. (Verfasst von) , Stratakis, Constantine A. (Verfasst von) , Brodeur, Garrett M. (Verfasst von) , Diller, Lisa R. (Verfasst von) , Kamihara, Junne (Verfasst von) , Malkin, David (Verfasst von) , Pajtler, Kristian Wilfried (Verfasst von) , Tamura, Chieko (Verfasst von) , Villani, Anita (Verfasst von) , Widjaja, Elysa (Verfasst von) , Das, Anirban (Verfasst von) , Rednam, Surya (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2 September 2025
In: Clinical cancer research
Year: 2025, Jahrgang: 31, Heft: 17, Pages: 3628-3637
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-24-3860
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-24-3860
Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/clincancerres/article/31/17/3628/764187/Updated-Recommendations-for-Pediatric-Surveillance
Volltext
Verfasserangaben:Jonathan D. Wasserman, Kami Wolfe Schneider, Maria-Isabel Achatz, Yoshiko Nakano, Kristin Zelley, Bailey Gallinger, Andrew J. Bauer, Kerri D. Becktell, Ari J. Wassner, Laura Raiti, Andrea S. Doria, Lisa J. States, Constantine A. Stratakis, Garrett M. Brodeur, Lisa R. Diller, Junne Kamihara, David Malkin, Kristian W. Pajtler, Chieko Tamura, Anita Villani, Elysa Widjaja, Anirban Das, and Surya P. Rednam
Beschreibung
Zusammenfassung:Hereditary endocrine neoplasia syndromes comprise multiple entities associated with an increased risk for the development of endocrine and nonendocrine neoplasms and other systemic manifestations. These syndromes typically demonstrate autosomal dominant inheritance, and each syndrome is associated with a unique genetic predisposition to a distinct spectrum of tumor susceptibility. Moreover, genotype-phenotype associations within each syndrome may affect the spectrum, penetrance, and age of onset of associated tumors. As many endocrine tumors are benign and/or indolent, a careful approach to monitoring is necessary, wherein the nature, timing of initiation, and frequency of presymptomatic surveillance balance the goal of detecting tumors at a point in which intervention would limit tumor-associated morbidity against the physical, emotional, and financial burdens of surveillance. In this study, we summarize changes in knowledge and practice recommendations related to children with multiple endocrine neoplasia syndromes (types 1, 2A, 2B, 4, and 5), hyperparathyroidism-jaw tumor syndrome, and Carney complex since an initial summary in 2017. These updates reflect the evolving understanding of these complex genetic disorders and aim to improve patient care and outcomes.
Beschreibung:Online veröffentlicht am: 25. Juni 2025
Gesehen am 27.05.2026
Beschreibung:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-24-3860

Ähnliche Einträge