Mavacamten in symptomatic nonobstructive hypertrophic cardiomyopathy

In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten.

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Detalles Bibliográficos
Autores principales: Desai, Milind (Autor) , Owens, Anjali T. (Autor) , Abraham, Theodore (Autor) , Olivotto, Iacopo (Autor) , García-Pavía, Pablo (Autor) , Lopes, Renato D. (Autor) , Elliott, Perry (Autor) , Fernandes, Fabio (Autor) , Verheyen, Nicolas (Autor) , Maier, Lars (Autor) , Meder, Benjamin (Autor) , Azevedo, Olga (Autor) , Kitaoka, Hiroaki (Autor) , Wolski, Kathy (Autor) , Wang, Qiuqing (Autor) , Jaber, Wael (Autor) , Mitchell, Lisa (Autor) , Myers, Jonathan (Autor) , Rano, Thomas (Autor) , Gong, Zhiqun (Autor) , Zhong, Yue (Autor) , Carter-Bonanza, Suzanne (Autor) , Florea, Victoria (Autor) , Aronson, Ron (Autor) , Nissen, Steven E. (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: September 11, 2025
In: The New England journal of medicine
Year: 2025, Volumen: 393, Número: 10, Pages: 961-972
ISSN:1533-4406
DOI:10.1056/NEJMoa2505927
Acceso en línea:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa2505927
Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2505927
Enlace del recurso
Notas de Autor:M.Y. Desai, A.T. Owens, T. Abraham, I. Olivotto, P. Garcia-Pavia, R.D. Lopes, P. Elliott, F. Fernandes, N. Verheyen, L. Maier, B. Meder, O. Azevedo, H. Kitaoka, K. Wolski, Q. Wang, W. Jaber, L. Mitchell, J. Myers, T. Rano, Z. Gong, Y. Zhong, S. Carter-Bonanza, V. Florea, R. Aronson, and S.E. Nissen
Descripción
Sumario:In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten.
Notas:Online veröffentlicht am: 30. August 2025
Gesehen am 27.05.2026
Descripción Física:Online Resource
ISSN:1533-4406
DOI:10.1056/NEJMoa2505927