Mavacamten in symptomatic nonobstructive hypertrophic cardiomyopathy
In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten.
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
September 11, 2025
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| In: |
The New England journal of medicine
Year: 2025, Volumen: 393, Número: 10, Pages: 961-972 |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa2505927 |
| Acceso en línea: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa2505927 Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2505927 |
| Notas de Autor: | M.Y. Desai, A.T. Owens, T. Abraham, I. Olivotto, P. Garcia-Pavia, R.D. Lopes, P. Elliott, F. Fernandes, N. Verheyen, L. Maier, B. Meder, O. Azevedo, H. Kitaoka, K. Wolski, Q. Wang, W. Jaber, L. Mitchell, J. Myers, T. Rano, Z. Gong, Y. Zhong, S. Carter-Bonanza, V. Florea, R. Aronson, and S.E. Nissen |
| Sumario: | In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten. |
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| Notas: | Online veröffentlicht am: 30. August 2025 Gesehen am 27.05.2026 |
| Descripción Física: | Online Resource |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa2505927 |