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Beyond the secretory pathway: new insights into protein release

In eukaryotes, protein secretion plays essential roles in intercellular communications and extracellular niche-building. Protein secretion generally requires a signal sequence that targets cargos to the canonical secretory pathway consisting of the endoplasmic reticulum (ER), the Golgi apparatus, pl...

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Autores principales: Chen, Ruey-hwa (Autor) , Costa-Filho, Antonio J. (Autor) , Debnath, Jayanta (Autor) , Galli, Thierry (Autor) , Ge, Liang (Autor) , Goberdhan, Deborah (Autor) , Guo, Wei (Autor) , He, Kangmin (Autor) , Jacob, Ralf (Autor) , Kang, Tiebang (Autor) , Lee, Min Goo (Autor) , Li, Lian (Autor) , Lolicato, Fabio (Autor) , Lu, Jun (Autor) , Malhotra, Vivek (Autor) , Nickel, Walter (Autor) , Nikoletopoulou, Vassiliki (Autor) , Ogden, Stacey K. (Autor) , Sagia, Georgia Maria (Autor) , Shao, Feng (Autor) , Shi, Anbing (Autor) , Thery, Clotilde (Autor) , Vérollet, Christel (Autor) , Villeneuve, Julien (Autor) , Verweij, Frederik (Autor) , Wang, Yanzhuang (Autor) , Wang, Juan (Autor) , Wu, Shenjie (Autor) , Ye, Yihong (Autor) , Yin, Hang (Autor) , Yu, Li (Autor) , Zhang, Min (Autor) , Zhang, Ying (Autor) , Zhou, Xin (Autor) , Zurzolo, Chiara (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 6 November 2025
In: Traffic
Year: 2025, Volumen: 26, Número: 10/12, Pages: 1-12
ISSN:1600-0854
DOI:10.1111/tra.70022
Acceso en línea:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/tra.70022
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tra.70022
Enlace del recurso
Notas de Autor:Ruey-Hwa Chen, Antonio J. Costa-Filho, Jayanta Debnath, Thierry Galli, Liang Ge, Deborah Goberdhan, Wei Guo, Kangmin He, Ralf Jacob, Tiebang Kang, Min Goo Lee, Lian Li, Fabio Lolicato, Jun Lu, Vivek Malhotra, Walter Nickel, Vassiliki Nikoletopoulou, Stacey K. Ogden, Georgia Maria Sagia, Feng Shao, Anbing Shi, Clotilde Thery, Christel Vérollet, Julien Villeneuve, Frederik Verweij, Yanzhuang Wang, Juan Wang, Shenjie Wu, Yihong Ye, Hang Yin, Li Yu, Min Zhang, Ying Zhang, Xin Zhou, Chiara Zurzolo
Descripción
Sumario:In eukaryotes, protein secretion plays essential roles in intercellular communications and extracellular niche-building. Protein secretion generally requires a signal sequence that targets cargos to the canonical secretory pathway consisting of the endoplasmic reticulum (ER), the Golgi apparatus, plasma membrane, and vesicles moving between these compartments. However, cytoplasmic proteins lacking signal sequences (e.g., IL1β, Acb1, FGF2) have been detected, and many have defined functions in the extracellular space, suggesting unconventional protein secretion (UcPS) via alternative pathways. In recent years, scientists have uncovered many new UcPS paradigms, reporting a plethora of mechanisms that collectively form a new field. The inaugural Cold Spring Harbor Asia (CSHA) conference on “Molecular Mechanisms and Physiology of Unconventional Secretion” is the first meeting to bring these researchers together, providing a collegial platform for information sharing at this exciting frontier of cell biology research.
Notas:Gesehen am 27.05.2026
Online veröffentlicht: 6. November 2025
Descripción Física:Online Resource
ISSN:1600-0854
DOI:10.1111/tra.70022

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