Penicillin allergy, really?- a cross-sectional mixed-methods study in Baden-Württemberg, Germany, to explore general practitioner perspectives on delabeling potential in primary care
Background: Most penicillin allergy labels are documented in early childhood and result from events of low risk for allergy. In Germany, evidence-based strategies to evaluate the likelihood of a true penicillin allergy are still lacking. As general practitioner input is indispensable regarding requi...
Salvato in:
| Autori principali: | , , , |
|---|---|
| Natura: | Article (Journal) |
| Lingua: | inglese |
| Pubblicazione: |
15 April 2026
|
| In: |
Antibiotics
Year: 2026, Volume: 15, Fascicolo: 4, Pages: 1-11 |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics15040399 |
| Accesso online: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/antibiotics15040399 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2079-6382/15/4/399 
|
| Note sull'autore: | Regina Poß-Doering, Nicola A. Litke, Elham Khatamzas and Attila Altiner |
| Riassunto: | Background: Most penicillin allergy labels are documented in early childhood and result from events of low risk for allergy. In Germany, evidence-based strategies to evaluate the likelihood of a true penicillin allergy are still lacking. As general practitioner input is indispensable regarding required resources for the implementation of successful delabeling strategies in outpatient care, a mixed-methods study in Baden-Württemberg, Germany explored untapped delabeling potential and conditions for successful initiatives based on their experiences, to support preservation of penicillin as a treatment option and prevent resistance development. Methods: A cross-sectional convergent mixed-methods study was conducted with an online survey and semi-structured interviews. The survey link and invitation to participate in an interview was sent to randomly selected publicly available e-mail addresses. Survey data were analyzed descriptively. Qualitative data were analyzed inductively based on thematic analysis. Results: n = 101 survey questionnaires and n = 15 interviews were analyzed regarding relevance, experiences, framework conditions, and potential approaches to delabeling. All participants with limited recollection of the index reaction. Most participants considered delabeling a highly relevant topic in general practice. Delabeling efforts were discouraged by lack of time, expertise, and remuneration, and uncertainty due to missing guidelines. Taking a sufficient medical history and, if necessary, subsequent testing were seen as one approach to delabeling. For a standardized approach in primary care, patient and care provider education, precise guideline recommendations, and delabeling expert teams were suggested. Conclusions: The findings mirror aspects already identified in international research. A nationwide survey with general practitioners could confirm that addressing necessary resources and systemic adjustments would support effective penicillin allergy delabeling in outpatient care. |
|---|---|
| Descrizione del documento: | Veröffentlicht: 15. April 2026 Gesehen am 28.05.2026 |
| Descrizione fisica: | Online Resource |
| ISSN: | 2079-6382 |
| DOI: | 10.3390/antibiotics15040399 |