Lost in projection?: Gaussian filtering recovers hidden conformational states
To interpret molecular dynamics (MD) simulations, it is common practice to reduce the dimensionality of the molecular coordinates to a low-dimensional collective variable x. Projecting the high-dimensional MD data onto x yields a free energy landscape ΔG(x), which highlights low-energy regions corre...
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| Autori principali: | , , , |
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| Natura: | Article (Journal) |
| Lingua: | inglese |
| Pubblicazione: |
16 April 2026
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| In: |
The journal of physical chemistry letters
Year: 2026, Volume: 17, Fascicolo: 15, Pages: 4418-4425 |
| ISSN: | 1948-7185 |
| DOI: | 10.1021/acs.jpclett.6c00341 |
| Accesso online: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1021/acs.jpclett.6c00341 Verlag, kostenfrei, Volltext: https://pubs.acs.org/doi/10.1021/acs.jpclett.6c00341?src=getftr&utm_source=clarivate&getft_integrator=clarivate 
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| Note sull'autore: | Sofia Sartore, Daniel Nagel, Georg Diez, and Gerhard Stock |
| Riassunto: | To interpret molecular dynamics (MD) simulations, it is common practice to reduce the dimensionality of the molecular coordinates to a low-dimensional collective variable x. Projecting the high-dimensional MD data onto x yields a free energy landscape ΔG(x), which highlights low-energy regions corresponding to conformational states. The accurate definition of these states, however, is often impeded by projection artifacts, resulting in artificially shortened state lifetimes or even the complete disappearance of states from the analysis. As demonstrated for a two-dimensional toy model, Gaussian low-pass filtering of the high-dimensional feature trajectory can restore the underlying free energy landscape, allowing recovery of previously hidden states. When applied to an all-atom folding trajectory of HP35, the number of microstates increases by an order of magnitude, which leads to metastable states that are long-lived and much better defined structurally, even compared to dynamically cored state trajectories. |
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| Descrizione del documento: | Online verfügbar: 02. April 2026 Gesehen am 01.06.2026 |
| Descrizione fisica: | Online Resource |
| ISSN: | 1948-7185 |
| DOI: | 10.1021/acs.jpclett.6c00341 |