Advancing CNS tumor diagnostics with expanded DNA methylation-based classification

DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted by the World Health Organization (WHO) classification of central nervous system (CNS) tumors. We present the Heidelberg CNS Tumor Methylation Classifier version 12.8 (v12.8), trained on 7,495 methylati...

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Main Authors:	Sill, Martin (Author) , Schrimpf, Daniel (Author) , Patel, Areeba (Author) , Sturm, Dominik (Author) , Jäger, Natalie (Author) , Sievers, Philipp (Author) , Schweizer, Leonille (Author) , Banan, Rouzbeh (Author) , Reuss, David (Author) , Suwala, Abigail Kora (Author) , Korshunov, Andrey (Author) , Stichel, Damian (Author) , Wefers, Annika K. (Author) , Hau, Ann-Christin (Author) , Boldt, Henning (Author) , Harter, Patrick Nikolaus (Author) , Abdullaev, Zied (Author) , Benhamida, Jamal (Author) , Teichmann, Daniel (Author) , Koch, Arend Wolfgang (Author) , Hench, Jürgen Christian Hans (Author) , Frank, Stephan (Author) , Hasselblatt, Martin (Author) , Mansouri, Sheila (Author) , Ståhl, Theresita Díaz de (Author) , Serrano, Jonathan (Author) , Ecker, Jonas (Author) , Selt, Florian (Author) , Taylor, Michael (Author) , Ramaswamy, Vijay (Author) , Cavalli, Florence M. G. (Author) , Bergmeister-Berghoff, Anna Sophie (Author) , Bison, Brigitte (Author) , Blattner-Johnson, Mirjam (Author) , Buchhalter, Ivo (Author) , Buslei, Rolf (Author) , Calaminus, Gabriele (Author) , Dikow, Nicola (Author) , Dohmen, Hildegard (Author) , Euskirchen, Philipp (Author) , Fleischhack, Gudrun (Author) , Gajjar, Amar (Author) , Gerber, Nicolas U. (Author) , Gessi, Marco (Author) , Gielen, Gerrit H. (Author) , Gnekow, Astrid K. (Author) , Gottardo, Nicholas G. (Author) , Haberler, Christine (Author) , Hamelmann, Stefan (Author) , Hans, Volkmar (Author) , Hansford, Jordan R. (Author) , Hartmann, Christian (Author) , Heppner, Frank L. (Author) , Hernáiz Driever, Pablo (Author) , Hoff, Katja von (Author) , Thomale, Ulrich-Wilhelm (Author) , Tippelt, Stephan (Author) , Frühwald, Michael (Author) , Kramm, Christof (Author) , Schüller, Ulrich (Author) , Schittenhelm, Jens Florian (Author) , Schuhmann, Martin Ulrich (Author) , Stein, Marco (Author) , Temming, Petra (Author) , Ladanyi, Marc (Author) , Jabado, Nada (Author) , Jones, Barbara Christine (Author) , Jones, Chris (Author) , Karajannis, Matthias A. (Author) , Ketter, Ralf (Author) , Kohlhof-Meinecke, Patricia (Author) , Kordes, Uwe (Author) , Reinhardt, Annekathrin (Author) , Kölsche, Christian (Author) , Lamszus, Katrin (Author) , Lichter, Peter (Author) , Maas, Sybren L. N. (Author) , Mawrin, Christian (Author) , Milde, Till (Author) , Mittelbronn, Michel Guy André (Author) , Monoranu, Camelia Maria (Author) , Müller, Wolf C. (Author) , Mynarek, Martin (Author) , Northcott, Paul A. (Author) , Pajtler, Kristian Wilfried (Author) , Paulus, Werner (Author) , Perry, Arie (Author) , Blümcke, Ingmar (Author) , Plate, Karl (Author) , Platten, Michael (Author) , Preusser, Matthias (Author) , Pietsch, Torsten (Author) , Prinz, Marco (Author) , Reifenberger, Guido (Author) , Kristensen, Bjarne Winther (Author) , Kool, Marcel (Author) , Hovestadt, Volker (Author) , Ellison, David W. (Author) , Jacques, Thomas S. (Author) , Varlet, Pascale (Author) , Etminan, Nima (Author) , Acker, Till (Author) , Weller, Michael (Author) , White, Christine (Author) , Witt, Olaf (Author) , Herold-Mende, Christel (Author) , Debus, Jürgen (Author) , Krieg, Sandro (Author) , Wick, Wolfgang (Author) , Snuderl, Matija (Author) , Aldape, Kenneth (Author) , Brandner, Sebastian (Author) , Hawkins, Cynthia (Author) , Horbinski, Craig (Author) , Thomas, Christian (Author) , Wesseling, Pieter (Author) , Deimling, Andreas von (Author) , Capper, David (Author) , Pfister, Stefan (Author) , Jones, David T. W. (Author) , Sahm, Felix (Author)
Format:	Article (Journal)
Language:	English
Published:	9 February 2026
In:	Cancer cell Year: 2026, Volume: 44, Issue: 2
ISSN:	1878-3686
DOI:	10.1016/j.ccell.2025.11.002
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ccell.2025.11.002 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610825004957
Author Notes:	Martin Sill, Daniel Schrimpf, Areeba Patel, Dominik Sturm, Natalie Jäger, Philipp Sievers, Rouzbeh Banan, David Reuss, Abigail Suwala, Damian Stichel, Annika K. Wefers, Jonas Ecker, Florian Selt, Nicola Dikow, Stefan Hamelmann, Barbara C. Jones, Chris Jones, Annekathrin Reinhardt, Peter Lichter, Till Milde, Kristian W. Pajtler, Karl H. Plate, Michael Platten, Marcel Kool, Nima Etminan, Olaf Witt, Christel Herold-Mende, Jürgen Debus, Sandro Krieg, Wolfgang Wick, Andreas von Deimling, Stefan M. Pfister, David T.W. Jones, Felix Sahm [und viele weitere]