Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany
Clostridioides difficile infections (CDI) present significant health risks and are among the most important nosocomial infections. Ribotype (RT) 027 poses a particular risk due to its proposed “hypervirulence”. Traditionally, C. difficile isolates are characterized using PCR-ribotyping. More recentl...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
28 May 2025
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| In: |
Antimicrobial resistance and infection control
Year: 2025, Volumen: 14, Pages: 1-10 |
| ISSN: | 2047-2994 |
| DOI: | 10.1186/s13756-025-01565-y |
| Acceso en línea: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s13756-025-01565-y Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s13756-025-01565-y 
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| Notas de Autor: | Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann and Mardjan Arvand |
| Sumario: | Clostridioides difficile infections (CDI) present significant health risks and are among the most important nosocomial infections. Ribotype (RT) 027 poses a particular risk due to its proposed “hypervirulence”. Traditionally, C. difficile isolates are characterized using PCR-ribotyping. More recently, whole genome sequence (WGS) analysis is increasingly used, which may provide a higher discriminatory power. This study aimed to assess the distribution of different C. difficile RTs in hospitals in the Berlin-Brandenburg area, and to analyse the heterogeneity within isolates of different ribotypes using WGS. |
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| Notas: | Gesehen am 09.06.2026 |
| Descripción Física: | Online Resource |
| ISSN: | 2047-2994 |
| DOI: | 10.1186/s13756-025-01565-y |