A photoreceptor state links aggressive brain tumors in children
In this issue of Cancer Cell, Gudenas et al. reveal that Group 3 medulloblastoma, pineoblastoma, and retinoblastoma converge on a shared tumor-associated photoreceptor signature rooted in transient developmental progenitors. This work reframes these malignancies as diseases of common developmental v...
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| Autori principali: | , |
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| Natura: | Article (Journal) |
| Lingua: | inglese |
| Pubblicazione: |
13 April 2026
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| In: |
Cancer cell
Year: 2026, Volume: 44, Fascicolo: 4, Pages: 713-714 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2026.02.014 |
| Accesso online: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccell.2026.02.014 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1535610826001121 
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| Note sull'autore: | Stefan M. Pfister and Lena M. Kutscher |
| Riassunto: | In this issue of Cancer Cell, Gudenas et al. reveal that Group 3 medulloblastoma, pineoblastoma, and retinoblastoma converge on a shared tumor-associated photoreceptor signature rooted in transient developmental progenitors. This work reframes these malignancies as diseases of common developmental vulnerability and identifies shared transcriptional dependencies with potential therapeutic relevance. |
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| Descrizione del documento: | Online verfügbar: 19. März 2026, Artikelversion: 13. April 2026 Gesehen am 10.06.2026 |
| Descrizione fisica: | Online Resource |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2026.02.014 |