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Mesoglea biogenesis reveals a cryptic aboral valve for pressure regulation in cnidarian morphogenesis

Cnidarians are classically defined by a single oral opening, a hallmark of the “blind gut” model in early animal evolution. Here, we identify a pressure-sensitive aboral valve in Nematostella vectensis that operates independently of egestion. This valve dissipates elevated hydraulic pressure during...

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Auteurs principaux: Basu, Soham (Auteur) , Steenbergen, Petrus (Auteur) , Gabler, Florian (Auteur) , Paix, Alexandre (Auteur) , Ronchi, Paolo (Auteur) , Bourenkov, Gleb (Auteur) , Schneider, Thomas R. (Auteur) , Hellgoth, Jonas (Auteur) , Kreshuk, Anna (Auteur) , Özbek, Suat (Auteur) , Ikmi, Aissam (Auteur)
Format: Article (Journal)
Langue:anglais
Publié: April 2026
In: Science advances
Year: 2026, Volume: 12, Numéro: 16, Pages: 1-13
ISSN:2375-2548
DOI:10.1126/sciadv.adz2530
Accès en ligne:Verlag, kostenfrei, Volltext: https://doi.org/10.1126/sciadv.adz2530
Verlag, kostenfrei, Volltext: https://www.science.org/doi/10.1126/sciadv.adz2530
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Notes sur l'auteur:Soham Basu, Petrus Steenbergen, Florian Gabler, Alexandre Paix, Paolo Ronchi, Gleb Bourenkov, Thomas R. Schneider, Jonas Hellgoth, Anna Kreshuk, Suat Özbek, Aissam Ikmi
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Résumé:Cnidarians are classically defined by a single oral opening, a hallmark of the “blind gut” model in early animal evolution. Here, we identify a pressure-sensitive aboral valve in Nematostella vectensis that operates independently of egestion. This valve dissipates elevated hydraulic pressure during morphogenesis, expelling fluid through transient epidermal ruptures triggered by muscular ring opening. This unexpected function was revealed by a comprehensive analysis of mesogleal basement membrane biogenesis. We show that the global dynamics of this extracellular matrix transduce muscular hydraulics to drive tissue rearrangement and stabilize shape, while localized FGFRb-dependent matrix remodeling establishes the aboral valve. By positioning the mesoglea as an integrator of biomechanics, tissue remodeling, and aboral valve function, these findings expand nonbilaterian openings beyond the digestive paradigm as a hydraulic regulator.
Description:Gesehen am 11.06.2026
Description matérielle:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.adz2530

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