Small subset, big impact: regulatory function of γδ T cells in arteriogenesis
Despite the identification of several mediators of arteriogenesis, the growth of natural bypass, the role of lymphocytes, particularly T cells, in this process remains poorly defined. Among these, γδ T cells, which express alternative T cell receptors, have emerged as a key immune component. This st...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
17 April 2026
|
| In: |
Cells
Year: 2026, Volumen: 15, Número: 8, Pages: 1-25 |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells15080709 |
| Acceso en línea: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cells15080709 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2073-4409/15/8/709 
|
| Notas de Autor: | Kira-Sofie Wimmer, Carolin Baur, Matthias Kübler, Christoph Arnholdt, Konda Kumaraswami, Franziska Heim, Katharina Elbs, Michael Reha Rohrmoser, Daphne Merkus and Elisabeth Deindl |
| Sumario: | Despite the identification of several mediators of arteriogenesis, the growth of natural bypass, the role of lymphocytes, particularly T cells, in this process remains poorly defined. Among these, γδ T cells, which express alternative T cell receptors, have emerged as a key immune component. This study examined the roles of αβ and γδ T cells in arteriogenesis using a murine hindlimb model. While the absence of αβ T cells did not affect arteriogenesis, γδ T cell depletion markedly reduced vascular cell proliferation and perfusion recovery. Early phase analyses revealed impaired mast cell activation, whereas platelet-neutrophil aggregates and neutrophil extravasation were unaffected. In the later proliferative phase, γδ T cell depletion hindered perivascular M2-like (MRC1+) macrophage accumulation. Flow cytometric analysis of whole blood in wildtype mice revealed a temporal shift in γδ T cell populations from a CD27+/CD39− phenotype, commonly associated with pro-inflammatory functions and IFNγ production, to CD39+ phenotypes, which have been linked to anti-inflammatory properties and IL-10 production. In rescue experiments, administration of IFNγ to γδ T cell-depleted mice restored mast cell activation, whereas IL-10 treatment reestablished M2-like (MRC1+) macrophage accumulation. These findings collectively identify γδ T cells as critical regulators of both early and late phases of arteriogenesis through coordinated inflammatory and regenerative mechanisms. |
|---|---|
| Notas: | Veröffentlicht: 17. April 2026 Gesehen am 11.06.2026 |
| Descripción Física: | Online Resource |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells15080709 |