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Bacteria use P-body condensates to attenuate host translation during infection

Pathogens use sophisticated strategies to modulate host protein homeostasis by targeting proteolytic pathways, but their impact on protein synthesis remains elusive. We report that pathogenic bacteria Pseudomonas syringae (Pst) targets ribonucleoprotein condensates, known as processing bodies (P-bod...

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Main Authors: González-Fuente, Manuel (Author) , Schulz, Nico (Author) , Abdrakhmanov, Alibek (Author) , Krüger, Thorben (Author) , Izzati, Gaiea (Author) , Zhu, Shanshuo (Author) , Langin, Gautier (Author) , Gouguet, Paul (Author) , Franz-Wachtel, Mirita (Author) , Macek, Boris (Author) , Hafrén, Anders (Author) , Dagdas, Yasin (Author) , Üstün, Suayib (Author)
Format: Article (Journal)
Language:English
Published: April 2026
In: Science advances
Year: 2026, Volume: 12, Issue: 17, Pages: 1-13
ISSN:2375-2548
DOI:10.1126/sciadv.aec4477
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1126/sciadv.aec4477
Verlag, kostenfrei, Volltext: https://www.science.org/doi/10.1126/sciadv.aec4477
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Author Notes:Manuel González-Fuente, Nico Schulz, Alibek Abdrakhmanov, Thorben Krüger, Gaiea Izzati, Shanshuo Zhu, Gautier Langin, Paul Gouguet, Mirita Franz-Wachtel, Boris Macek, Anders Hafrén, Yasin Dagdas, Suayib Üstün
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Summary:Pathogens use sophisticated strategies to modulate host protein homeostasis by targeting proteolytic pathways, but their impact on protein synthesis remains elusive. We report that pathogenic bacteria Pseudomonas syringae (Pst) targets ribonucleoprotein condensates, known as processing bodies (P-bodies), to attenuate host translation through two effectors with liquid-like properties. We uncovered a previously unknown link that Pst-mediated repression of the endoplasmic reticulum stress response is required for P-body assembly. Furthermore, we identify a functional link between P-bodies and autophagy, demonstrating that autophagic clearance of P-bodies is crucial for maintaining the balance between translationally active and inactive messenger RNAs. Together, our findings provide insights on how host translation is attenuated by bacteria to dampen plant immunity and uncover unknown connections between ER stress responses and autophagy with P-body dynamics.
Item Description:Veröffentlicht: 24. April 2026
Gesehen am 12.06.2026
Physical Description:Online Resource
ISSN:2375-2548
DOI:10.1126/sciadv.aec4477

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