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From bench to triage: diagnostic utility of delta-like canonical notch ligand-1 (DLL-1) for early sepsis prediction in the emergency department

The early identification of patients with sepsis among those presenting with suspected infection in the emergency department (ED) remains challenging. Delta-like canonical Notch ligand-1 (DLL-1), a Notch pathway ligand involved in immune and endothelial signaling, has been shown to reflect disease s...

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Main Authors: Hübner, Aurelia (Author) , Friedrich, Katharina (Author) , Galtung, Noa (Author) , Theobald, Vivienne (Author) , Schenz, Judith (Author) , Hecke, Britta (Author) , Kraß, Melanie (Author) , Weigand, Markus A. (Author) , Kappert, Kai (Author) , Bauer, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: 2026
In: Infection
Year: 2026, Volume: 54, Issue: 3, Pages: 1547-1557
ISSN:1439-0973
DOI:10.1007/s15010-026-02794-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s15010-026-02794-y
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Author Notes:Aurelia Hübner, Katharina Friedrich, Noa Galtung, Vivienne Theobald, Judith Schenz, Britta Hecke, Melanie Kraß, Markus A. Weigand, Kai Kappert, Wolfgang Bauer
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Summary:The early identification of patients with sepsis among those presenting with suspected infection in the emergency department (ED) remains challenging. Delta-like canonical Notch ligand-1 (DLL-1), a Notch pathway ligand involved in immune and endothelial signaling, has been shown to reflect disease severity and outcomes in ICU-based sepsis cohorts. Its value for early risk stratification at ED presentation is less well defined.
Item Description:Online veröffentlicht: 13. April 2026
Gesehen am 19.06.2026
Physical Description:Online Resource
ISSN:1439-0973
DOI:10.1007/s15010-026-02794-y

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