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Intraoperative radiotherapy after resection of newly diagnosed brain metastases in adult patients: results of a prospective phase II trial (INTRAMET)

Brain metastases occur in approximately 20% of cancer patients. Surgical resection followed by radiotherapy is a standard approach for symptomatic lesions. Intraoperative radiotherapy (IORT) enables immediate irradiation of the resection cavity and may facilitate treatment integration. We conducted...

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Main Authors: Brehmer, Stefanie (Author) , Sarria, Gustavo R. (Author) , Würfel, Sara (Author) , Sulejmani, Ardita (Author) , Schneider, Frank (Author) , Clausen, Sven (Author) , Abo-Madyan, Yasser (Author) , Ruder, Arne Mathias (Author) , Sperk, Elena (Author) , Etminan, Nima (Author) , Giordano, Frank Anton (Author)
Format: Article (Journal)
Language:English
Published: 28 May 2026
In: Journal of neuro-oncology
Year: 2026, Volume: 178, Pages: 1-13
ISSN:1573-7373
DOI:10.1007/s11060-026-05649-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-026-05649-6
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s11060-026-05649-6
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Author Notes:Stefanie Brehmer, Gustavo R. Sarria, Sara Würfel, Ardita Sulejmani, Frank Schneider, Sven Clausen, Yasser Abo-Madyan, Arne M. Ruder, Elena Sperk, Nima Etminan, Frank A. Giordano
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Summary:Brain metastases occur in approximately 20% of cancer patients. Surgical resection followed by radiotherapy is a standard approach for symptomatic lesions. Intraoperative radiotherapy (IORT) enables immediate irradiation of the resection cavity and may facilitate treatment integration. We conducted a prospective phase-II-trial to evaluate the efficacy and safety of low-energy X-ray IORT following resection of brain metastases.
Item Description:Gesehen am 30.06.2026
Physical Description:Online Resource
ISSN:1573-7373
DOI:10.1007/s11060-026-05649-6

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