Comparison of 1.1-mm and 1.7-mm probes in transbronchial mediastinal cryobiopsy: a randomized trial
Introduction - Recent studies have shown that combined use of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and cryobiopsy provides a higher diagnostic yield for mediastinal lesions as compared with EBUS-TBNA alone. Currently, cryoprobes with diameters of 1.1mm and 1.7...
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Article (Journal) |
| Lingua: | inglese |
| Pubblicazione: |
2 May 2026
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| In: |
Archivos de bronconeumología
Year: 2026, Volume: 62, Fascicolo: 5, Pages: 310-316 |
| ISSN: | 1579-2129 |
| DOI: | 10.1016/j.arbres.2026.01.015 |
| Accesso online: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.arbres.2026.01.015 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0300289626000438 
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| Note sull'autore: | Ren-Hai Zhong, Na Wu, Yi-Ding Li, Jing Zhang, Wan-Lei Fu, Zan-Sheng Huang, Yu Zhang, Shuo-Xin Zhang, Yun-Qiu Jiang, Yuan-Yuan Yu, Konstantina Kontogianni, Felix J.F. Herth, Ye Fan, Yan Zhang |
| Riassunto: | Introduction - Recent studies have shown that combined use of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and cryobiopsy provides a higher diagnostic yield for mediastinal lesions as compared with EBUS-TBNA alone. Currently, cryoprobes with diameters of 1.1mm and 1.7mm have been reported to be used for mediastinal cryobiopsy. - Methods - We conducted a randomized controlled trial to evaluate and compare the diagnostic safety and efficacy profile the two cryoprobes in mediastinal disease. Consecutive patients with mediastinal lesions (≥1cm in the short axis) were prospectively enrolled. After four passes of needle aspiration, participants underwent mediastinal cryobiopsy with 1.1-mm and 1.7-mm cryoprobes in a randomized order. The main endpoints included procedural success rate, diagnostic yield, and safety. - Results - A total of 137 patients were recruited and randomized. Both 1.1-mm and 1.7-mm probe cryobiopsies added diagnostic value to EBUS-TBNA. (94.2% vs 75.9%; p<0.001; 92.0% vs 75.9%; p<0.001; respectively). Supplementing EBUS-TBNA with either 1.1-mm or 1.7-mm probe-cryobiopsy resulted in no differences in overall diagnostic yield (94.2% vs 92.0%; p=0.48). Nevertheless, direct comparison revealed a significantly improved overall diagnostic yield with 1.1-mm cryoprobe relative to 1.7-mm cryoprobe, primarily due to technical failures associated with the latter (88.3% vs 79.6%; p=0.048). Additionally, 1.1-mm and 1.7-mm cryoprobes yielded mediastinal specimens of similar size. Both approaches were safe, with no serious adverse events reported. - Conclusions - 1.1-mm cryoprobe demonstrates better performance in transbronchial mediastinal cryobiopsy vs 1.7-mm cryoprobe, making it a viable adjunct to traditional needle biopsy. |
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| Descrizione del documento: | Online verfügbar 31 January 2026, Version des Artikels 2 May 2026 Gesehen am 01.07.2026 |
| Descrizione fisica: | Online Resource |
| ISSN: | 1579-2129 |
| DOI: | 10.1016/j.arbres.2026.01.015 |