Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis

AXIN1 is a central regulatory hub of many oncogenic pathways in colorectal cancer (CRC). As the main scaffold protein and least abundant component of the beta-catenin destruction complex, changes in AXIN1 levels tightly control Wnt signaling activity. How other cancer pathways beyond Wnt signaling r...

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Main Authors:	Venkatachalam, Nachiyappan (Author) , Wang, Li (Author) , Muthukumarana, Niyumi (Author) , Ihnatko, Robert (Author) , Krijgsveld, Jeroen (Author) , Skabkina, Olga Valerievna (Author) , Leipertz, A. (Author) , Chen, Yubin (Author) , Sui, Ping (Author) , Zheng, Qing (Author) , Tong, Panpan (Author) , Liu, Xi (Author) , Descot, Arnaud (Author) , Schewe, Matthias (Author) , Diamante, Gabriele (Author) , Jackstadt, René-Filip (Author) , Brochhausen, Christoph (Author) , Betge, Johannes (Author) , Boonekamp, Kim E. (Author) , Boutros, Michael (Author) , Stoecklin, Georg (Author) , Ebert, Matthias (Author) , Schott, Johanna (Author) , Zhan, Tianzuo (Author)
Format:	Article (Journal)
Language:	English
Published:	27 May 2026
In:	Cell communication and signaling Year: 2026, Volume: 24, Pages: 1-22
ISSN:	1478-811X
DOI:	10.1186/s12964-026-02963-4
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12964-026-02963-4 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s12964-026-02963-4
Author Notes:	Nachiyappan Venkatachalam, Li Wang, Niyumi Muthukumarana, Robert Ihnatko, Jeroen Krijgsveld, Olga Skabkina, Antonia Leipertz, Yubin Chen, Ping Sui, Qing Zheng, Panpan Tong, Xi Liu, Arnaud Descot, Matthias Schewe, Gabriele Diamante, Rene Jackstadt, Christoph Brochhausen, Johannes Betge, Kim Boonekamp, Michael Boutros, Georg Stoecklin, Matthias Ebert, Johanna Schott and Tianzuo Zhan