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Paradigms for microbiome analysis in infectious and non-communicable diseases

Next-generation sequencing and bioinformatics paved the way in deciphering the human gut microbiome and challenged fundamental postulates on the causal role of the microbiota for health and pathogenesis of infectious and noncommunicable diseases. To exploit the clinical relevance and potential of mi...

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Hauptverfasser: Autenrieth, Ingo B. (Verfasst von) , Bury, Laetitia (Verfasst von) , Rooney, Ashley M. (Verfasst von) , Willmann, Matthias (Verfasst von) , Vehreschild, Maria J. G. T. (Verfasst von) , Egli, Adrian (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 5 May 2026
In: Trends in microbiology
Year: 2026, Jahrgang: 34, Heft: 5, Pages: 472-484
ISSN:1878-4380
DOI:10.1016/j.tim.2025.11.016
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.tim.2025.11.016
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0966842X25003634
Volltext
Verfasserangaben:Ingo B. Autenrieth, Laetitia Bury, Ashley M. Rooney, Matthias Willmann, Maria J.G.T. Vehreschild, and Adrian Egli
Beschreibung
Zusammenfassung:Next-generation sequencing and bioinformatics paved the way in deciphering the human gut microbiome and challenged fundamental postulates on the causal role of the microbiota for health and pathogenesis of infectious and noncommunicable diseases. To exploit the clinical relevance and potential of microbiome diagnostics and therapy, deep metagenomic sequencing with standardized, validated laboratory procedures, aiming at deciphering the microbiome at strain level and applying index-scores to allow classification of individual microbiomes as dysbiotic (associated with disease) or eubiotic (associated with health) should be implemented. By this means, metagenomically informed therapies with live biotherapeutic products, fecal microbiota transfer, pro-, pre-, or postbiotics might become a standard in personalized prevention and treatment of infectious and non-communicable diseases.
Beschreibung:Gesehen am 06.07.2026
Online verfügbar 17 December 2025, Version des Artikels 5 May 2026
Beschreibung:Online Resource
ISSN:1878-4380
DOI:10.1016/j.tim.2025.11.016

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