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Do we need early detection of grade group 2 prostate cancer in a screening program for young men?: Results from the PROBASE screening trial

In general, low-risk and favorable intermediate-risk prostate cancers (PCs; International Society of Urological Pathology grade group [GG] 1 and GG 2) are slow-growing cancers with low metastatic potential. Active surveillance is recommended for GG 1 PC and can be recommended for GG 2 PC in the abse...

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Autori principali: Albers, Peter (Autore) , Krilaviciute, Agne (Autore) , Seibold, Petra (Autore) , de Vrieze, Maxime (Autore) , Lakes, Jale (Autore) , Kuczyk, Markus A. (Autore) , Harke, Nina N. (Autore) , Debus, Jürgen (Autore) , Grott, Christoph A. (Autore) , Gschwend, Jürgen E. (Autore) , Herkommer, Kathleen (Autore) , Soehne, Victoria A. (Autore) , Benner, Axel (Autore) , Kristiansen, Glen (Autore) , Hadaschik, Boris (Autore) , Arsov, Christian (Autore) , Antoch, Gerald (Autore) , Schimmöller, Lars (Autore) , Giesel, Frederik L. (Autore) , Makowski, Marcus R. (Autore) , Wacker, Frank (Autore) , Schlemmer, Heinz-Peter (Autore) , Kaaks, Rudolf (Autore) , Becker, Nikolaus (Autore)
Natura: Article (Journal) Editorial
Lingua:inglese
Pubblicazione: April 2026
In: European urology oncology
Year: 2026, Volume: 9, Fascicolo: 2, Pages: 211-214
ISSN:2588-9311
DOI:10.1016/j.euo.2025.06.007
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.euo.2025.06.007
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2588931125001865
Testo
Note sull'autore:Peter Albers, Agne Krilaviciute, Petra Seibold, Maxime de Vrieze, Jale Lakes, Markus A. Kuczyk, Nina N. Harke, Jürgen Debus, Christoph A. Grott, Jürgen E. Gschwend, Kathleen Herkommer, Victoria A. Soehne, Axel Benner, Glen Kristiansen, Boris Hadaschik, Christian Arsov, Gerald Antoch, Lars Schimmöller, Frederik L. Giesel, Marcus R. Makowski, Frank Wacker, Heinz-Peter Schlemmer, Rudolf Kaaks, Nikolaus Becker
Descrizione
Riassunto:In general, low-risk and favorable intermediate-risk prostate cancers (PCs; International Society of Urological Pathology grade group [GG] 1 and GG 2) are slow-growing cancers with low metastatic potential. Active surveillance is recommended for GG 1 PC and can be recommended for GG 2 PC in the absence of adverse pathological parameters. Therefore, the question arises as to when low-grade PC should be detected in a screening setting. We conducted an analysis of the group with intermediate prostate-specific antigen (PSA) risk (1.5-2.99 ng/ml) from the PROBASE screening trial for young men (starting age 45 yr) and evaluated 159 biopsies performed for confirmed PSA ≥3 ng/ml in the first two biennial screening rounds. Of these biopsies, 37% were positive, with 78% (46/59) showing GG 1 or GG 2 disease. Only 0.8% of men with intermediate risk (13 of 1661 men screened) had GG 3-5 PC and would have experienced a delay in diagnosis of between 1 and 3 yr if screening were performed at 5-yr intervals. These results suggest that the screening interval could be extended from 2 yr to 5 yr for men aged 45 yr at intermediate risk, similar to the interval for men at low risk (PSA <1.5 ng/ml). This would reduce unnecessary testing and overdiagnosis in nearly 10% of the screening population aged 45 yr.
Descrizione del documento:Online verfügbar 10 July 2025, Version des Artikels 28 April 2026
Gesehen am 09.07.2026
Descrizione fisica:Online Resource
ISSN:2588-9311
DOI:10.1016/j.euo.2025.06.007

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