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Investigating hepatitis E virus seroprevalence in patients with Alzheimer’s disease

BackgroundHepatitis E virus (HEV) exposure has been linked to neurologic manifestations and dementia. This study aims to clarify a possible association between HEV and Alzheimer’s disease (AD).MethodsWe performed a single-center retrospective case-control study of 453 cognitively impaired adults fro...

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Main Authors: Capraru, Tiberiu Daniel (Author) , Bauer, Tim Christopher (Author) , Jordan, Paula (Author) , Weidner, Niklas (Author) , Oensal, Melisa (Author) , Frölich, Lutz (Author) , Beisel, Claudia (Author) , Hausner, Lucrezia (Author) , Dao Thi, Viet Loan (Author)
Format: Article (Journal)
Language:English
Published: 07 May 2026
In: Frontiers in aging neuroscience
Year: 2026, Volume: 18, Pages: 1-6
ISSN:1663-4365
DOI:10.3389/fnagi.2026.1831973
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fnagi.2026.1831973
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1831973/full
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Author Notes:Tiberiu Daniel Capraru, Tim Christopher Bauer, Paula Jordan, Niklas M. Weidner, Melisa Oensal, Lutz Froelich, Claudia Beisel, Lucrezia Hausner and Viet Loan Dao Thi
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Summary:BackgroundHepatitis E virus (HEV) exposure has been linked to neurologic manifestations and dementia. This study aims to clarify a possible association between HEV and Alzheimer’s disease (AD).MethodsWe performed a single-center retrospective case-control study of 453 cognitively impaired adults from southern Germany, comparing anti-HEV IgG seropositivity between patients with AD and those with non-AD cognitive impairment. Associations were evaluated using chi-square testing and multivariable logistic regression, including age-stratified analyses.ResultsOverall HEV IgG seroprevalence was higher in the AD group than in the non-AD group (44.5% vs. 37.7%, p = 0.138), with a significant difference in patients aged 60-69 years (46.5% vs. 35.1%, p = 0.040) but not in those aged 70-79 years (46.7% vs. 50.0%, p = 0.646).ConclusionThese findings suggest that anti-HEV antibodies are more frequent in younger elderly AD patients compared with cognitively impaired individuals of the same age without AD, raising the hypothesis that prior HEV infection may represent a candidate environmental risk factor for AD.
Item Description:Gesehen am 09.07.2026
Physical Description:Online Resource
ISSN:1663-4365
DOI:10.3389/fnagi.2026.1831973

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