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Fiber intake associates with increased treatment response in patients with multiple myeloma along with changes in gut microbiome: to the editor : research letter

TO THE EDITOR:Multiple myeloma (MM) remains an incurable plasma-cell malignancy, and depth of response, particularly the achievement of minimal residual disease (MRD) negativity, correlates with long-term survival.1 Increasing evidence indicates that the gut microbiome and its metabolites shape syst...

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Autori principali: Sester, Lilli Sophie (Autore) , Galeeva, Iuliia (Autore) , Castilhos, Juliana de (Autore) , Borisov, Vadim (Autore) , Gambihler, Anna K. (Autore) , Kilian, Michael (Autore) , Vonhören, David (Autore) , Friedrich, Mirco (Autore) , Poschet, Gernot (Autore) , Steiger, Simon (Autore) , Chechenina, Anna (Autore) , Lettau, Konstanze Kora (Autore) , Kohlberger, Chris P. (Autore) , Prokoph, Nina (Autore) , Frenking, Jan (Autore) , John, Lukas (Autore) , Huhn, Stefanie (Autore) , Reichert, Philipp (Autore) , Mai, Elias K. (Autore) , Rippe, Karsten (Autore) , Sauer, Sandra (Autore) , Müller-Tidow, Carsten (Autore) , Weinhold, Niels (Autore) , Platten, Michael (Autore) , Goldschmidt, Hartmut (Autore) , Raab, Marc-Steffen (Autore) , Stein-Thöringer, Christoph (Autore)
Natura: Article (Journal) Editorial
Lingua:inglese
Pubblicazione: 12 May 2026
In: Blood advances
Year: 2026, Volume: 10, Fascicolo: 9, Pages: 3088-3093
ISSN:2473-9537
DOI:10.1182/bloodadvances.2025018598
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1182/bloodadvances.2025018598
Testo
Note sull'autore:Lilli S. Sester, Iuliia Galeeva, Juliana de Castilhos, Vadim Borisov, Anna K. Gambihler, Michael Kilian, David Vonhören, Mirco J. Friedrich, Gernot Poschet, Simon Steiger, Anna Chechenina, Konstanze Lettau, Chris P. Kohlberger, Nina Prokoph, Jan Frenking, Lukas John, Stefanie Huhn, Philipp Reichert, Elias K. Mai, Karsten Rippe, Sandra Sauer, Carsten Müller-Tidow, Niels Weinhold, Michael Platten, Hartmut Goldschmidt, Marc-Steffen Raab, and Christoph K. Stein-Thoeringer
Descrizione
Riassunto:TO THE EDITOR:Multiple myeloma (MM) remains an incurable plasma-cell malignancy, and depth of response, particularly the achievement of minimal residual disease (MRD) negativity, correlates with long-term survival.1 Increasing evidence indicates that the gut microbiome and its metabolites shape systemic immune function and influence treatment outcomes in MM.2,3 For instance, depletion of short-chain fatty acid (SCFA)-producing bacteria was found in patients with MM,4 and higher SCFA abundance has been associated with superior therapeutic responses.3,5 A recent dietary intervention study demonstrated that a high-fiber plant-based diet favorably modulates the gut microbiome and immune milieu in myeloma precursor disorders.6 Building on these observations, we hypothesized that dietary fiber intake modulates microbiome composition and correlates with clinical outcomes in patients with newly diagnosed MM (NDMM).
Descrizione del documento:Gesehen am 13.07.2026
Descrizione fisica:Online Resource
ISSN:2473-9537
DOI:10.1182/bloodadvances.2025018598

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