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Wire-calibrated induction of segmental ureteral strictures in rats via midline laparotomy

Ureteral strictures remain a major challenge in reconstructive urology and can arise from iatrogenic injury, chronic inflammation, trauma, congenital anomalies, or radiation.​ These lesions frequently lead to progressive obstructive uropathy and loss of renal function. Despite advances in...

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Hauptverfasser: Studier-Fischer, Alexander (Verfasst von) , Grützner, Paula (Verfasst von) , Özdemir, Berkin (Verfasst von) , Haney, Caelán Max (Verfasst von) , Knoedler, Samuel (Verfasst von) , Renner, Luisa Vivienne (Verfasst von) , Carl, Nicolas (Verfasst von) , Clanget, Tilmann (Verfasst von) , Salg, Gabriel Alexander (Verfasst von) , Westhoff, Niklas Christian (Verfasst von) , Michel, Maurice Stephan (Verfasst von) , Kowalewski, Karl-Friedrich (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 17th, 2026
In: JoVE journal. Neuroscience
Year: 2026, Heft: 230
ISSN:1940-087X
DOI:10.3791/70726
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3791/70726
Verlag, lizenzpflichtig, Volltext: https://www.jove.com/t/70726/wire-calibrated-induction-segmental-ureteral-strictures-rats-via
Volltext
Verfasserangaben:Alexander Studier-Fischer, Paula Grützner, Berkin Özdemir, Caelan Max Haney, Samuel Knoedler, Luisa Renner, Nicolas Carl, Tilmann Clanget, Gabriel Alexander Salg, Niklas Westhoff, Maurice Stephan Michel, Karl-Friedrich Kowalewski
Beschreibung
Zusammenfassung:Ureteral strictures remain a major challenge in reconstructive urology and can arise from iatrogenic injury, chronic inflammation, trauma, congenital anomalies, or radiation.​ These lesions frequently lead to progressive obstructive uropathy and loss of renal function. Despite advances in endoscopic and surgical techniques, ureteral strictures remain challenging to address, and their remodeling effects on the renal parenchyma remain the subject of ongoing research, underscoring the need for robust preclinical models. This study establishes a reproducible rat model for controlled induction of various degrees of segmental ureteral strictures using wire‑calibrated partial ligation via midline laparotomy. The protocol enables segmental, non‑transecting constriction of the ureter, intended to approximate fibrotic narrowing at a functional and anatomical level while minimizing evident ischemic damage and maintaining macroscopic tissue viability with ureteral continuity. By providing a reliable experimental platform with low inter‑animal and inter-surgeon variability, this approach supports translational research on biomolecular mechanisms, biomaterials, imaging modalities, and reconstructive techniques for ureteral stricture disease.
Beschreibung:Gesehen am 13.07.2026
Beschreibung:Online Resource
ISSN:1940-087X
DOI:10.3791/70726

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