Copertina

Pancreatic resection with perioperative drug repurposing of propranolol and etodolac: the phase II randomized controlled PROSPER trial

The perioperative period is characterized by psychological stress and inflammatory reactions that can contribute to disease recurrence or metastatic spread. These reactions are mediated particularly by catecholamines and prostaglandins. The PROSPER trial aimed to evaluate whether a perioperative dru...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Hüttner, Felix (Autore) , Klotz, Rosa (Autore) , Giese, Nathalia (Autore) , Kong, Bo (Autore) , Ahmed, Azaz (Autore) , Merz, Daniela (Autore) , Pöchmann, Alexandra (Autore) , Burghaus, Ina (Autore) , Hackert, Thilo (Autore) , Strobel, Oliver (Autore) , Mihaljevic, André Leopold (Autore) , Michalski, Christoph (Autore) , Büchler, Markus W. (Autore) , Diener, Markus K. (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 22 May 2025
In: Langenbeck's archives of surgery
Year: 2025, Volume: 410, Fascicolo: 1, Pages: 1-12
ISSN:1435-2451
DOI:10.1007/s00423-025-03735-3
Accesso online:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1007/s00423-025-03735-3
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00423-025-03735-3
Testo
Note sull'autore:Felix J. Hüttner, Rosa Klotz, Nathalia A. Giese, Bo Kong, Azaz Ahmed, Daniela Merz, Alexandra Pöchmann, Ina Burghaus, Thilo Hackert, Oliver Strobel, André L. Mihaljevic, Christoph W. Michalski, Markus W. Büchler, Markus K. Diener
Descrizione
Riassunto:The perioperative period is characterized by psychological stress and inflammatory reactions that can contribute to disease recurrence or metastatic spread. These reactions are mediated particularly by catecholamines and prostaglandins. The PROSPER trial aimed to evaluate whether a perioperative drug repurposing with a non-selective betablocker (propranolol) and a COX-2 inhibitor (etodolac) is feasible and safe in the setting of pancreatic cancer surgery.
Descrizione del documento:Gesehen am 15.07.2026
Descrizione fisica:Online Resource
ISSN:1435-2451
DOI:10.1007/s00423-025-03735-3

Documenti analoghi