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Subretinal drusenoid deposits (reticular pseudodrusen) in the general population: a European multicohort study : clinical science

Background/aims To investigate the prevalence and determinants of subretinal drusenoid deposits (SDDs; also known as reticular pseudodrusen, RPDs) in the European general population. - Methods Altogether 18 931 adults from eight population-based studies were included. SDDs/RPDs were determined on op...

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Main Authors: Mauschitz, Matthias (Author) , Holz, Frank G. (Author) , Schuster, Alexander K. (Author) , Grabitz, Stephanie D. (Author) , Jonas, Jost B. (Author) , Bikbov, Mukharram M. (Author) , Kazakbaeva, Gyulli M. (Author) , Hogg, Ruth (Author) , Peto, Tunde (Author) , Creuzot-Garcher, Catherine P. (Author) , Gabrielle, Pierre-Henry (Author) , Coimbra, Rita (Author) , Farinha, Cláudia (Author) , Delcourt, Cecile (Author) , Cougnard-Grégoire, Audrey (Author) , Brandl, Caroline (Author) , Heid, Iris M. (Author) , Finger, Robert P. (Author)
Format: Article (Journal)
Language:English
Published: 2026
In: British journal of ophthalmology
Year: 2026, Pages: 1-7
ISSN:1468-2079
DOI:10.1136/bjo-2025-329334
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/bjo-2025-329334
Verlag, lizenzpflichtig, Volltext: https://bjo.bmj.com/content/early/2026/06/07/bjo-2025-329334
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Author Notes:Matthias M. Mauschitz, Frank G. Holz, Alexander K. Schuster, Stephanie D. Grabitz, Jost B. Jonas, Mukharram M. Bikbov, Gyulli M. Kazakbaeva, Ruth Hogg, Tunde Peto, Catherine P. Creuzot-Garcher, Pierre-Henry Gabrielle, Rita Coimbra, Cláudia Farinha, Cecile Delcourt, Audrey Cougnard-Grégoire, Caroline Brandl, Iris M. Heid, Robert P. Finger
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Summary:Background/aims To investigate the prevalence and determinants of subretinal drusenoid deposits (SDDs; also known as reticular pseudodrusen, RPDs) in the European general population. - Methods Altogether 18 931 adults from eight population-based studies were included. SDDs/RPDs were determined on optical coherence tomography and/or infrared photography. The prevalence of SDDs/RPDs and associated ocular and systemic determinants using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis were analysed. - Results Mean age ranged from 58.7±10.6 to 88.4±0.0 years in the different studies and prevalence of SDDs/RPDs ranged from 0.6% to 56.0%. Meta-analyses showed that increasing age (OR 1.09 per year, 95% CI 1.04 to 1.13; p<0.001), prevalent early/intermediate and late age-related macular degeneration (AMD) (OR 10.93, 95% CI 5.55 to 21.51; p<0.001 and OR 11.65, 95% CI 4.78 to 28.40; p<0.001, respectively) and AMD genetic risk score (OR 1.21 per unit, 95% CI 1.05 to 1.39; p=0.008) are associated with prevalent SDDs/RPDs. Sex, smoking, education and cardiovascular disease showed borderline association at some cohort levels but not in the meta-analysis. In sensitivity analyses, only age and AMD genetic risk score remained associated with SDDs/RPDs prevalence among participants without any AMD. - Conclusions This multi-cohort analysis emphasises the wide range of SDDs/RPDs prevalence and determinants. Besides age, presence of AMD and AMD genetic risk variants increase the risk of SDDs/RPDs. These cross-sectional findings are compatible with the hypothesis that SDDs/RPDs may not represent a separate disease entity but be an additional sign of retinal pigment epithelium and photoreceptor stress.
Item Description:Erstmals veröffentlicht: 8. Juni 2026
Gesehen am 16.07.2026
Physical Description:Online Resource
ISSN:1468-2079
DOI:10.1136/bjo-2025-329334

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