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Associations of ANGPTL3/4/8 proteins and complexes with heart failure and heart failure mortality

Angiopoietin-like 3/4/8 (ANGPTL3/4/8) proteins play critical roles in modulating lipid metabolism through calorically sensitive and tissue-specific regulation of lipoprotein lipase (LPL) activity via formation of ANGPTL3/8 and ANGPTL4/8 complexes. ANGPTL3/4/8 proteins are also associated with cardio...

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Autori principali: Silbernagel, Günther (Autore) , Maas, Ann-Cathrin (Autore) , Li, Hongxia (Autore) , Lemen, Deven (Autore) , Chen, Yan Q. (Autore) , Zhen, Eugene Y. (Autore) , Wen, Yi (Autore) , Kleber, Marcus E. (Autore) , Delgado Gonzales de Kleber, Graciela (Autore) , Moissl-Blanke, Angela P. (Autore) , März, Winfried (Autore) , Niessner, Alexander (Autore) , Scharnagl, Hubert (Autore) , Konrad, Robert J. (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 07 May 2026
In: Lipids in health and disease
Year: 2026, Volume: 25, Fascicolo: 1, Pages: 1-9
ISSN:1476-511X
DOI:10.1186/s12944-026-02973-8
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12944-026-02973-8
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s12944-026-02973-8
Testo
Note sull'autore:Günther Silbernagel, Ann-Cathrin Maas, Hongxia Li, Deven Lemen, Yan Q. Chen, Eugene Y. Zhen, Yi Wen, Marcus E. Kleber, Graciela Delgado, Angela P. Moissl, Winfried März, Alexander Niessner, Hubert Scharnagl and Robert J. Konrad
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Riassunto:Angiopoietin-like 3/4/8 (ANGPTL3/4/8) proteins play critical roles in modulating lipid metabolism through calorically sensitive and tissue-specific regulation of lipoprotein lipase (LPL) activity via formation of ANGPTL3/8 and ANGPTL4/8 complexes. ANGPTL3/4/8 proteins are also associated with cardiovascular risk. Circulating levels of ANGPTL3, ANGPTL4/8, and C-terminal domain-containing ANGPTL4 (CD-ANGPTL4) have been associated with overall cardiovascular mortality. In this study, we investigated the associations of ANGPTL3/4/8 proteins and complexes with heart failure (HF) and HF death.
Descrizione del documento:Online veröffentlicht: 7. Mai 2026, Artikelversion: 30. Juni 2026
Gesehen am 20.07.2026
Descrizione fisica:Online Resource
ISSN:1476-511X
DOI:10.1186/s12944-026-02973-8

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