Long-term outcomes across age and risk profiles in a caucasian living kidney donor cohort
Living kidney donation achieves excellent recipient outcomes, but increasingly involves older and medically complex donors, while long-term data across age groups remain limited. The Heidelberg Kidney Donor Study followed 632 donors (1991-2020), stratified by age <40 (n = 93), 40-60 (n = 424), an...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
April 2026
|
| In: |
Transplant international
Year: 2026, Volumen: 39, Pages: 1-17 |
| ISSN: | 1432-2277 |
| DOI: | 10.3389/ti.2026.16266 |
| Acceso en línea: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/ti.2026.16266 Verlag, kostenfrei, Volltext: https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2026.16266/full 
|
| Notas de Autor: | Claudia Sommerer, Iris Schröter, Nicola Marie Kuhlmann, Zoi Bougioukou and Martin Zeier |
| Sumario: | Living kidney donation achieves excellent recipient outcomes, but increasingly involves older and medically complex donors, while long-term data across age groups remain limited. The Heidelberg Kidney Donor Study followed 632 donors (1991-2020), stratified by age <40 (n = 93), 40-60 (n = 424), and >60 years (n = 115). Primary outcomes were a ≥50% eGFR decline and an eGFR <45 mL/min/1.73 m2 at long-term follow-up. Early post-donation adaptation, long-term eGFR trajectories, cardiovascular events, and risk patterns were evaluated. Mean donor age was 50.6 ± 10.6 years (62.5% female). eGFR declined by 26.0% after donation and remained stable thereafter. At a median follow-up of 12 years, ≥50% eGFR decline occurred in 4.8%, 5.3%, and 14.4% of donors aged <40, 40-60, and >60 years, respectively, an eGFR <45 mL/min/1.73 m2 in 1.2%, 5.3%, and 20.4%. An eGFR <30 mL/min/1.73 m2 occurred in 1.2%, major adverse cardiovascular events in 4.3%. Age, hypertension, and baseline-eGFR independently predicted renal impairment. Younger donors with hypertension or obesity had up to a 14.3% risk of ≥50% eGFR decline, exceeding the risk in healthy older donors (12.5%). Living kidney donation was associated with stable long-term kidney function after early adaptation, with substantial heterogeneity driven more by baseline renal reserve and comorbidity than chronological age alone. |
|---|---|
| Notas: | Veröffentlicht: 23. April 2026 Gesehen am 24.07.2026 |
| Descripción Física: | Online Resource |
| ISSN: | 1432-2277 |
| DOI: | 10.3389/ti.2026.16266 |