Imagen de Portada

Macrophage at maternal-fetal interface: perspective on pregnancy and related disorders

Immune cells at the maternal-fetal interface (MFI) undergo dynamic changes to facilitate fetal growth and development during pregnancy. In contrast to the adaptive immune system, where effector T cells, Tregs, and suppressor T cells play key roles in maintaining immune tolerance toward the semi-allo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Duan, Haoran (Autor) , Deng, Weinan (Autor) , Kzhyshkowska, Julia (Autor) , Chen, Dunjin (Autor) , Zhang, Shuang (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 12 June 2026
In: Placenta
Year: 2026, Volumen: 180, Pages: 87-99
ISSN:1532-3102
DOI:10.1016/j.placenta.2025.05.005
Acceso en línea:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.placenta.2025.05.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0143400425001584
Enlace del recurso
Notas de Autor:Haoran Duan, Weinan Deng, Julia Kzhyshkowska, Dunjin Chen, Shuang Zhang
Descripción
Sumario:Immune cells at the maternal-fetal interface (MFI) undergo dynamic changes to facilitate fetal growth and development during pregnancy. In contrast to the adaptive immune system, where effector T cells, Tregs, and suppressor T cells play key roles in maintaining immune tolerance toward the semi-allogeneic fetus, the innate immune system—comprising decidual nature killer (dNK) cells, macrophages, and dendritic cells (DCs)—makes up a significant portion of the decidual leukocyte population. These innate immune cells are crucial in modulating trophoblast invasion, spiral artery remodeling, and apoptotic cell phagocytosis. Dysregulation of the innate immune system has been linked to impaired uterine vessel remodeling and defective trophoblast invasion, which can lead to complications such as spontaneous abortion, preeclampsia (PE), and preterm. This review focuses on recent advancements in understanding the innate immune defenses at the maternal-fetal interface and their connections to pregnancy-related diseases, with particular emphasis on the role of macrophages.
Notas:Online verfügbar: 9. Mai 2025, Artikelversion: 3. Juni 2026
Gesehen am 27.07.2026
Descripción Física:Online Resource
ISSN:1532-3102
DOI:10.1016/j.placenta.2025.05.005

Ejemplares similares