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Safety and pharmacokinetics of intravitreally repeatedly injected panitumumab in non-human primates: a study performed under good laboratory practice

Epidermal growth factor (EGF) has been suggested to play a role in myopic axial elongation, and EGF receptor blockade may be of potential therapeutic benefit. Here we examined the ocular and systemic toxicity of panitumumab, a clinically used EGF receptor blocker in oncology, when repeatedly adminis...

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Autori principali: Wang, Ya Xing (Autore) , Holz, Frank G. (Autore) , Coenen, Martin (Autore) , Sun, Xinmin (Autore) , Xie, Wankun (Autore) , Panda-Jonas, Songhomitra (Autore) , Dong, Li (Autore) , Jonas, Jost B. (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 21 May 2026
In: BMC ophthalmology
Year: 2026, Volume: 26, Pages: 1-9
ISSN:1471-2415
DOI:10.1186/s12886-026-04909-3
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12886-026-04909-3
Testo
Note sull'autore:Ya Xing Wang, Frank G. Holz, Martin Coenen, Xinmin Sun, Wankun Xie, Songhomitra Panda-Jonas, Li Dong and Jost B. Jonas
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Riassunto:Epidermal growth factor (EGF) has been suggested to play a role in myopic axial elongation, and EGF receptor blockade may be of potential therapeutic benefit. Here we examined the ocular and systemic toxicity of panitumumab, a clinically used EGF receptor blocker in oncology, when repeatedly administered intravitreally in non-human primates.
Descrizione del documento:Online veröffentlicht: 21. Mai 2026, Artikelversion: 15. Juli 2026
Gesehen am 31.07.2026
Descrizione fisica:Online Resource
ISSN:1471-2415
DOI:10.1186/s12886-026-04909-3

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