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Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease

Chronic kidney disease (CKD) is increasingly associated with cognitive impairment, yet the molecular pathways connecting systemic inflammation to synaptic dysfunction remain unclear. This study investigates the role of the Ccl4-Ccr5 axis in microglia-mediated synaptic phagocytosis during CKD-associa...

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Detalles Bibliográficos
Autores principales: Cao, Yaochen (Autor) , Wang, Jingyun (Autor) , Li, Xitong (Autor) , Chen, Xin (Autor) , Xiong, Jinsheng (Autor) , Wang, Tianyao (Autor) , Sun, Hongming (Autor) , Wang, Ziqiang (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 25 May 2026
In: Journal of neuroinflammation
Year: 2026, Volumen: 23, Pages: 1-26
ISSN:1742-2094
DOI:10.1186/s12974-026-03852-w
Acceso en línea:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12974-026-03852-w
Enlace del recurso
Notas de Autor:Yaochen Cao, Jingyun Wang, Xitong Li, Xin Chen, Jinsheng Xiong, Tianyao Wang, Hongming Sun and Ziqiang Wang
Descripción
Sumario:Chronic kidney disease (CKD) is increasingly associated with cognitive impairment, yet the molecular pathways connecting systemic inflammation to synaptic dysfunction remain unclear. This study investigates the role of the Ccl4-Ccr5 axis in microglia-mediated synaptic phagocytosis during CKD-associated cognitive decline.
Notas:Online veröffentlicht: 25. Mai 2026, Artikelversion: 17. Juli 2026
Gesehen am 31.07.2026
Descripción Física:Online Resource
ISSN:1742-2094
DOI:10.1186/s12974-026-03852-w

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