Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease
Chronic kidney disease (CKD) is increasingly associated with cognitive impairment, yet the molecular pathways connecting systemic inflammation to synaptic dysfunction remain unclear. This study investigates the role of the Ccl4-Ccr5 axis in microglia-mediated synaptic phagocytosis during CKD-associa...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Article (Journal) |
| Langue: | anglais |
| Publié: |
25 May 2026
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| In: |
Journal of neuroinflammation
Year: 2026, Volume: 23, Pages: 1-26 |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/s12974-026-03852-w |
| Accès en ligne: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12974-026-03852-w
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| Notes sur l'auteur: | Yaochen Cao, Jingyun Wang, Xitong Li, Xin Chen, Jinsheng Xiong, Tianyao Wang, Hongming Sun and Ziqiang Wang |
| Résumé: | Chronic kidney disease (CKD) is increasingly associated with cognitive impairment, yet the molecular pathways connecting systemic inflammation to synaptic dysfunction remain unclear. This study investigates the role of the Ccl4-Ccr5 axis in microglia-mediated synaptic phagocytosis during CKD-associated cognitive decline. |
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| Description: | Online veröffentlicht: 25. Mai 2026, Artikelversion: 17. Juli 2026 Gesehen am 31.07.2026 |
| Description matérielle: | Online Resource |
| ISSN: | 1742-2094 |
| DOI: | 10.1186/s12974-026-03852-w |