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The sex-dependent relationship between amygdala activation and depressive symptoms with problematic drinking : archival report

Background - Although the initiation of alcohol consumption is common during adolescence, some individuals engage in binge drinking behavior that could lead to harmful consequences such as developing alcohol use disorder later in life. Evidence suggests a relationship between depressive symptoms and...

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Main Authors: Rosenthal, Annika (Author) , Rothkirch, Marcus (Author) , Krasniqi, Samanda (Author) , Bode, Erik L. (Author) , Daedelow, Laura S. (Author) , Banaschewski, Tobias (Author) , Barker, Gareth J. (Author) , Bokde, Arun L. W. (Author) , Brühl, Rüdiger (Author) , Desrivières, Sylvane (Author) , Flor, Herta (Author) , Garavan, Hugh (Author) , Gowland, Penny (Author) , Grigis, Antoine (Author) , Martinot, Jean-Luc (Author) , Paillère Martinot, Marie-Laure (Author) , Artiges, Eric (Author) , Nees, Frauke (Author) , Orfanos, Dimitri Papadopoulos (Author) , Poustka, Luise (Author) , Smolka, Michael (Author) , Holz, Nathalie E. (Author) , Vaidya, Nilakshi (Author) , Walter, Henrik (Author) , Whelan, Robert (Author) , Wirsching, Paul (Author) , Schumann, Gunter (Author) , Heinz, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 1 August 2026
In: Biological psychiatry
Year: 2026, Volume: 100, Issue: 3, Pages: 317-325
ISSN:1873-2402
DOI:10.1016/j.biopsych.2026.02.007
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.biopsych.2026.02.007
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0006322326000636
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Author Notes:Annika Rosenthal, Marcus Rothkirch, Samanda Krasniqi, Erik L. Bode, Laura S. Daedelow, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Nathalie Holz, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Paul Wirsching, Gunter Schumann, and Andreas Heinz, on behalf of the IMAGEN Consortium
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Summary:Background - Although the initiation of alcohol consumption is common during adolescence, some individuals engage in binge drinking behavior that could lead to harmful consequences such as developing alcohol use disorder later in life. Evidence suggests a relationship between depressive symptoms and harmful alcohol consumption that seems to vary depending on sex. Furthermore, it has been suggested that amygdala activation in response to negative emotional stimuli influences drinking due to depressive mood states. Therefore, we expected a sex-dependent effect of neuronal activation and depressive symptoms on risky drinking. - Methods - Here, we tested our hypothesis using a large dataset of 19-year-old participants (n = 958) in the IMAGEN study. Amygdala activation during an emotional faces task was extracted and entered into sex-moderated mediation models that also included scores from the Alcohol Use Disorders Identification Test and the Adolescent Depression Rating Scale. - Results - Moderated mediation models indicated that amygdala activation was associated with hazardous drinking through enhanced depressive symptoms in males, while amygdala reactivity in females was associated with decreased risky drinking. - Conclusions - Taken together, our findings reveal sex differences in negative emotional processing in at-risk adolescents. These associations have the potential to inform the development of sex-specific strategies as well as the detection of early neuronal risk factors to effectively curtail alcohol risk behavior.
Item Description:Online verfügbar: 19. Februar 2026, Artikelversion: 8. Juli 2026
Gesehen am 04.08.2026
Physical Description:Online Resource
ISSN:1873-2402
DOI:10.1016/j.biopsych.2026.02.007

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