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Brain network correlates of fatigue, depression, and anxiety in patients with Crohn’s Disease in different disease states

Symptoms of fatigue, depression or anxiety are frequent in Crohn’s Disease (CD) and may relate to disturbed brain-gut interactions. While more prevalent in active disease, these symptoms are also experienced by many individuals with CD during remission. Little is known about neural networks underlyi...

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Autori principali: Thomann, Anne K. (Autore) , Schmitgen, Mike (Autore) , Stephan, Jule C. (Autore) , Knödler, Laura-Louise (Autore) , Thomann, Philipp (Autore) , Szabo, Kristina (Autore) , Ebert, Matthias (Autore) , Reindl, Wolfgang (Autore) , Wolf, Robert Christian (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 09 July 2026
In: BMC gastroenterology
Year: 2026, Volume: 26, Pages: 1-11
ISSN:1471-230X
DOI:10.1186/s12876-026-05097-6
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12876-026-05097-6
Testo
Note sull'autore:Anne Kerstin Thomann, Mike Michael Schmitgen, Jule Cara Stephan, Laura-Louise Knoedler, Philipp Arthur Thomann, Kristina Szabo, Matthias Philip Ebert, Wolfgang Reindl and Robert Christian Wolf
Descrizione
Riassunto:Symptoms of fatigue, depression or anxiety are frequent in Crohn’s Disease (CD) and may relate to disturbed brain-gut interactions. While more prevalent in active disease, these symptoms are also experienced by many individuals with CD during remission. Little is known about neural networks underlying such extraintestinal symptoms in CD and their relationship with the current disease state. Using a data fusion approach for functional MRI, this study investigated spatiotemporal markers of resting-state brain activity and associations with neurotransmitter systems and symptoms of fatigue, depression or anxiety in an active disease state or remission.
Descrizione del documento:Online veröffentlicht: 9. Juli 2026, Artikelversion: 10. Juli 2026
Gesehen am 05.08.2026
Descrizione fisica:Online Resource
ISSN:1471-230X
DOI:10.1186/s12876-026-05097-6

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