Two-photon responsive amphiphilic photoswitches as molecular modulators of lipid order and curvature
Molecular photoswitches capable of - controlling membrane properties - under light stimulation represent promising tools for manipulating biomimetic and biological interfaces. We report the synthesis and photophysical characterization of amphiphilic P-type photoswitches - exhibiting efficient and re...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Langue: | anglais |
| Publié: |
May 19, 2026
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| In: |
Langmuir
Year: 2026, Volume: 42, Numéro: 19, Pages: 13267-13284 |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/acs.langmuir.5c06345 |
| Accès en ligne: | Verlag, kostenfrei, Volltext: https://doi.org/10.1021/acs.langmuir.5c06345
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| Notes sur l'auteur: | Aline Makhloutah, Jérémy Pecourneau, Cédric Mittelheisser, Anastasiia Delova, Ibrahim Abdellah, Stéphane Parant, Maxime Mourer, Yann Bernhard, Antonio Monari, Motomu Tanaka, and Andreea Pasc |
| Résumé: | Molecular photoswitches capable of - controlling membrane properties - under light stimulation represent promising tools for manipulating biomimetic and biological interfaces. We report the synthesis and photophysical characterization of amphiphilic P-type photoswitches - exhibiting efficient and reversible E↔Z photoisomerization under both one-photon (1PA: 375/300 - nm) and two-photon (2PA: 750/630 nm) excitation. Their incorporation - into DPPC monolayers and bilayers enables light-driven modulation - of membrane structure. Short-chain analogues (C4 derivatives) - remain well-mixed with DPPC and promote curvature upon E↔Z photoisomerization, regardless of the - polarity of their headgroup (hydroxyl, OH, or hexaethylenglycol, HEG). - In contrast, long-chain derivatives (C12) behave either - as light-activated compressants or expanders depending on the strength of their headgroup interactions. The HEG-terminated - C12 photoswitch (Sw-HEG-C12) favors - anchoring at the interface and induces lateral demixing (microsegregation) - and domain stiffening, leading to a decrease in surface pressure in - DPPC monolayers and an increase in vesicle size upon E→Z isomerization. Conversely, the hydroxylated - analogue (Sw-OH-C12) mixes nearly ideally - with DPPC but occupies different depths within the bilayer depending - on isomerization state (E near the interface, Z internalized), resulting in an increase in surface pressure - and a decrease in vesicle size upon E→Z isomerization. The two-photon-responsive photoswitches - reported herein appear thus as versatile tools for the optical control - of membrane architecture in biological environments where NIR light - is required. |
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| Description: | Veröffentlicht: 5. Mai 2026 Gesehen am 10.08.2026 |
| Description matérielle: | Online Resource |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/acs.langmuir.5c06345 |