Copertina

Two-photon responsive amphiphilic photoswitches as molecular modulators of lipid order and curvature

Molecular photoswitches capable of - controlling membrane properties - under light stimulation represent promising tools for manipulating biomimetic and biological interfaces. We report the synthesis and photophysical characterization of amphiphilic P-type photoswitches - exhibiting efficient and re...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Makhloutah, Aline (Autore) , Pecourneau, Jérémy (Autore) , Mittelheisser, Cédric (Autore) , Delova, Anastasiia (Autore) , Abdellah, Ibrahim (Autore) , Parant, Stéphane (Autore) , Mourer, Maxime (Autore) , Bernhard, Yann (Autore) , Monari, Antonio (Autore) , Tanaka, Motomu (Autore) , Pasc, Andreea (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: May 19, 2026
In: Langmuir
Year: 2026, Volume: 42, Fascicolo: 19, Pages: 13267-13284
ISSN:1520-5827
DOI:10.1021/acs.langmuir.5c06345
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1021/acs.langmuir.5c06345
Testo
Note sull'autore:Aline Makhloutah, Jérémy Pecourneau, Cédric Mittelheisser, Anastasiia Delova, Ibrahim Abdellah, Stéphane Parant, Maxime Mourer, Yann Bernhard, Antonio Monari, Motomu Tanaka, and Andreea Pasc
Descrizione
Riassunto:Molecular photoswitches capable of - controlling membrane properties - under light stimulation represent promising tools for manipulating biomimetic and biological interfaces. We report the synthesis and photophysical characterization of amphiphilic P-type photoswitches - exhibiting efficient and reversible E↔Z photoisomerization under both one-photon (1PA: 375/300 - nm) and two-photon (2PA: 750/630 nm) excitation. Their incorporation - into DPPC monolayers and bilayers enables light-driven modulation - of membrane structure. Short-chain analogues (C4 derivatives) - remain well-mixed with DPPC and promote curvature upon E↔Z photoisomerization, regardless of the - polarity of their headgroup (hydroxyl, OH, or hexaethylenglycol, HEG). - In contrast, long-chain derivatives (C12) behave either - as light-activated compressants or expanders depending on the strength of their headgroup interactions. The HEG-terminated - C12 photoswitch (Sw-HEG-C12) favors - anchoring at the interface and induces lateral demixing (microsegregation) - and domain stiffening, leading to a decrease in surface pressure in - DPPC monolayers and an increase in vesicle size upon E→Z isomerization. Conversely, the hydroxylated - analogue (Sw-OH-C12) mixes nearly ideally - with DPPC but occupies different depths within the bilayer depending - on isomerization state (E near the interface, Z internalized), resulting in an increase in surface pressure - and a decrease in vesicle size upon E→Z isomerization. The two-photon-responsive photoswitches - reported herein appear thus as versatile tools for the optical control - of membrane architecture in biological environments where NIR light - is required.
Descrizione del documento:Veröffentlicht: 5. Mai 2026
Gesehen am 10.08.2026
Descrizione fisica:Online Resource
ISSN:1520-5827
DOI:10.1021/acs.langmuir.5c06345

Documenti analoghi