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Implementing whole genome and transcriptome sequencing for cancer patients in routine healthcare: a comprehensive guide to costing

Molecular characterisation of solid tumours contributes to a precise diagnosis and can uncover a range of drug targets and biomarkers, improving patient management. Whole genome sequencing (WGS) combined with whole transcriptome sequencing (WTS) is the most comprehensive approach in molecular cancer...

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Main Authors: Altbürger, Christian (Author) , Menzel, Michael (Author) , Beck, Susanne (Author) , Lorenz, Katja (Author) , Brygider, Marie-Luise (Author) , Plöger, Carolin (Author) , Kahles, Andy (Author) , Ball, Markus (Author) , Kirchner, Martina (Author) , Schnecko, Fabian (Author) , Jung, Andreas (Author) , Klauschen, Frederick (Author) , Grob, Tobias (Author) , Horst, David (Author) , Hirsch, Daniela (Author) , Evert, Matthias (Author) , Schirmacher, Peter (Author) , Budczies, Jan (Author) , Kazdal, Daniel (Author) , Stenzinger, Albrecht (Author)
Format: Article (Journal)
Language:English
Published: 07 April 2026
In: British journal of cancer
Year: 2026, Volume: 134, Issue: 12, Pages: 1810-1819
ISSN:1532-1827
DOI:10.1038/s41416-026-03422-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41416-026-03422-0
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41416-026-03422-0
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Author Notes:Christian Altbürger, Michael Menzel, Susanne Beck, Katja Lorenz, Marie-Luise Brygider, Carolin Ploeger, Andy Kahles, Markus Ball, Martina Kirchner, Fabian Schnecko, Andreas Jung, Frederick Klauschen, Tobias Grob, David Horst, Daniela Hirsch, Matthias Evert, Peter Schirmacher, Jan Budczies, Daniel Kazdal, Albrecht Stenzinger
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Summary:Molecular characterisation of solid tumours contributes to a precise diagnosis and can uncover a range of drug targets and biomarkers, improving patient management. Whole genome sequencing (WGS) combined with whole transcriptome sequencing (WTS) is the most comprehensive approach in molecular cancer diagnostics and is therefore becoming increasingly integrated in clinical care. A critical challenge in implementing WGS/WTS as a clinical-grade test is its high cost compared to targeted sequencing approaches, prohibiting wider use and access.
Item Description:Gesehen am 04.08.2026
Online veröffentlicht: 7. April 2026
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/s41416-026-03422-0

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