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Accelerating translation of NK cell therapies to the clinic: a European perspective

Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatment for eligible pat...

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Auteurs principaux: Knapp, Lea Rebecca (Auteur) , Fischer, Katharina Sophie (Auteur) , Sosat, Janika (Auteur) , Villena-Ossa, Jose Francisco (Auteur) , Kluge, Pia (Auteur) , Schmiedel, Dominik (Auteur) , Kuball, Jürgen (Auteur) , Dolstra, Harry (Auteur) , Minguet, Susana (Auteur) , Cornu, Tatjana I. (Auteur) , Cathomen, Toni (Auteur) , Alici, Evren (Auteur) , O’Dwyer, Michael (Auteur) , Wels, Winfried Stephan (Auteur) , Malmberg, Karl-Johan (Auteur) , Romee, Rizwan (Auteur) , Vivier, Eric (Auteur) , Köhl, Ulrike (Auteur) , Cerwenka, Adelheid (Auteur) , Ullrich, Evelyn (Auteur)
Format: Article (Journal)
Langue:anglais
Publié: August 3, 2026
In: Human gene therapy
Year: 2026, Volume: 34, Numéro: 15-16
ISSN:1557-7422
DOI:10.1177/10430342261468974
Accès en ligne:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/10430342261468974
Verlag, lizenzpflichtig, Volltext: https://journals-sagepub-com.ezproxy.medma.uni-heidelberg.de/doi/10.1177/10430342261468974
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Notes sur l'auteur:Lea Rebecca Knapp, Katharina Sophie Fischer, Janika Sosat, Jose Francisco Villena-Ossa, Pia Kluge, Dominik Schmiedel, Jürgen Kuball, Harry Dolstra, Susana Minguet, Tatjana I. Cornu, Toni Cathomen, Evren Alici, Michael O’Dwyer, Winfried Stephan Wels, Karl-Johan Malmberg, Rizwan Romee, Eric Vivier, Ulrike Köhl, Adelheid Cerwenka, and Evelyn Ullrich
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Résumé:Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatment for eligible patients. In addition, natural killer (NK) cells and γδ T cells are of particular interest for cell-based therapies due to their strong intrinsic cytotoxicity and favorable safety profile. Addressing challenges facing the clinical translation of NK cell therapies was one of the issues discussed in the NK & ILC Symposium that took place in Freiburg, Germany from March 11 to 13, 2026, as the annual meeting of the NK & ILC study group of the German Society for Immunology (DGfI). Topics ranging from basic immunological research to technological innovations and clinical trial results were discussed during the 3-day conference, spanning over 40 presentations and 100 posters. A highlight of the conference was a workshop featuring short presentations and a panel discussion that focused specifically on the current challenges and future prospects of the clinical implementation of NK cell therapies; the findings of this workshop are summarized in this opinion paper.
Description:Gesehen am 13.08.2026
Description matérielle:Online Resource
ISSN:1557-7422
DOI:10.1177/10430342261468974

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