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Association of viral load in plasma samples of HIV-infected hemophilia patients with autoantibodies and gp120-containing immune complexes on CD4+ lymphocytes

Objective: We investigated whether the induction of antilymphocyte autoantibodies and immune complexes is associated with the activity of HIV replication. Methods: Viral HIV-1 RNA was measured in the plasma samples of 84 HIV+ hemophilia patients and correlated with the IgM, IgG, IgM/IgG and IgM/IgG/...

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Hauptverfasser: Daniel, Volker (Verfasst von) , Süsal, Caner (Verfasst von) , Weimer, Rolf (Verfasst von) , Zipperle, Silvia (Verfasst von) , Kröpelin, Marianne (Verfasst von) , Melk, Anette (Verfasst von) , Zimmermann, Rainer Johannes (Verfasst von) , Huth-Kühne, Angela (Verfasst von) , Opelz, Gerhard (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: February 1998
In: Immunology letters
Year: 1998, Jahrgang: 60, Heft: 2, Pages: 179-187
ISSN:1879-0542
DOI:10.1016/S0165-2478(97)00159-4
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0165-2478(97)00159-4
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165247897001594
Volltext
Verfasserangaben:Volker Daniel, Caner Süsal, Rolf Weimer, Silvia Zipperle, Marianne Kröpelin, Anette Melk, Rainer Zimmermann, Angela Huth-Kühne, Gerhard Opelz
Beschreibung
Zusammenfassung:Objective: We investigated whether the induction of antilymphocyte autoantibodies and immune complexes is associated with the activity of HIV replication. Methods: Viral HIV-1 RNA was measured in the plasma samples of 84 HIV+ hemophilia patients and correlated with the IgM, IgG, IgM/IgG and IgM/IgG/gp120 load of circulating CD4+ lymphocytes, CD4+ and CD8+ cell counts, plasma neopterin levels and in vitro T-cell responses to mitogens and pooled allogeneic stimulator cells. Results: Compared to patients with no immune complexes, on circulating CD4+ lymphocytes, viral load was increased in patients with IgM, IgM/IgG or IgM/IgG/gp120 complexes. Sequential analysis of HIV+ patients showed that peaks of retroviral activity were associated with the subsequent formation of CD4+ lymphocyte-reactive IgM and IgG autoantibodies and gp120-containing immune complexes. Conclusion: The induction of autoantibodies and immune complexes attached to CD4+ lymphocytes is associated with periods of increased viral activity in HIV-infected patients.
Beschreibung:Online verfügbar: 21. Mai 1998
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Beschreibung:Online Resource
ISSN:1879-0542
DOI:10.1016/S0165-2478(97)00159-4

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