Effect of preoperative intranasal insulin on postoperative delirium in adult surgical patients: a systematic review, meta-analysis, and trial sequential analysis

Postoperative delirium (POD) is a frequent and serious complication, especially in older adults and high-risk surgical patients. Intranasal insulin has emerged as a potential neuroprotective intervention, possibly modulating neuroinflammation and preserving cognitive function. This study aimed to ev...

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Autori principali:	Velasco, Emmanuel Mark M. (Autore) , Lima, Vinicius Sepúlveda (Autore) , Caldonazo, Tulio (Autore) , Passos, Felipe S. (Autore) , Lins, Paulo Ricardo Gessolo (Autore) , Grillo, Iago Teles Costa (Autore) , Tanaka, Pedro (Autore) , Macario, Alex (Autore) , Živković, Aleksandar (Autore) , ManoelSilva, João da (Autore) , Ehler, Johannes (Autore) , Esper Treml, Ricardo (Autore)
Natura:	Article (Journal)
Lingua:	inglese
Pubblicazione:	2026
In:	Perioperative medicine Year: 2026, Volume: 15, Pages: 1-14
ISSN:	2047-0525
DOI:	10.1186/s13741-026-00674-5
Accesso online:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13741-026-00674-5
Note sull'autore:	Emmanuel Mark M. Velasco, Vinicius Sepúlveda Lima, Tulio Caldonazo, Felipe S. Passos, Paulo Ricardo Gessolo Lins, Iago Teles Costa Grillo, Pedro Tanaka, Alex Macario, Aleksandar R. Zivkovic, João da ManoelSilva, Johannes Ehler and Ricardo Esper Treml