A 3D T1-weighted gradient-echo sequence for routine use in 3D radiosurgical treatment planning of brain metastases: first clinical results
The authors report on a 3D sequence for MRI of the brain and its application in radiosurgical treatment planning of 35 brain metastases. The measuring sequence, called magnetization — prepared rapid gradient echo (MPRAGE), was compared with 2D T1-weighted spin-echo (SE) sequences following intraveno...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
February 1995
|
| In: |
European radiology
Year: 1995, Volumen: 5, Número: 1, Pages: 19-25 |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/BF00178075 |
| Acceso en línea: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF00178075
|
| Notas de Autor: | H. Hawighorst, L.R. Schad, G. Gademann, S. Blüml, M.V. Knopp, F. Wenz, G. van Kaick |
| Sumario: | The authors report on a 3D sequence for MRI of the brain and its application in radiosurgical treatment planning of 35 brain metastases. The measuring sequence, called magnetization — prepared rapid gradient echo (MPRAGE), was compared with 2D T1-weighted spin-echo (SE) sequences following intravenous contrast-medium application in 19 patients with brain metastases. The average diameter of all lesions was similar in both sequences, with 16.8 and 17.0 mm for SE and MPRAGE, respectively. Target point definition was equal in 29 metastases, and in 6 cases superior on MPRAGE, due to better gray-white matter contrast and increased contrast enhancement. In cases of bleeding metastases there was improved depiction of internal structures in 3D MRI. Postprocessing of 3D MPRAGE data created multi-planar reconstruction along any chosen plane with isotropic spatial resolution, which helped to improve radiosurgical isodose distribution in 4 cases when compared to 2D SE. However, sensitivity of 3D MPRAGE to detect small lesions (< 3 mm) was decreased in one patient with more than 50 metastases. We conclude that 3D gradient-echo (GE) imaging might be of great value for radiosurgical treatment planning, but does not replace 2D SE with its current parameters. |
|---|---|
| Notas: | Gesehen am 26.08.2026 |
| Descripción Física: | Online Resource |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/BF00178075 |