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Clinical utility of proenkephalin A 119-159 for prediction of worsening renal function and prognosis in patients with sepsis -results of a patient-level meta-analysis

Proenkephalin A 119-159 (penKid) is a functional kidney biomarker inversely correlating with the glomerular filtration rate. We conducted a patient-level meta-analysis to evaluate whether penKid provides additional value to serum creatinine (sCr) for assessing kidney function and outcome in patients...

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Detalles Bibliográficos
Autores principales: Arlt, Birte (Autor) , Caironi, Pietro (Autor) , Meessen, Jennifer (Autor) , Hartmann, Oliver (Autor) , Mebazaa, Alexandre (Autor) , Legrand, Matthieu (Autor) , Gayat, Etienne (Autor) , Nußhag, Christian (Autor) , Brenner, Thorsten (Autor) , Laterre, Pierre François (Autor) , Tinelli, Ornella (Autor) , Latini, Roberto (Autor) , Uhle, Florian (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: 2026
In: Critical care
Year: 2026, Volumen: 30, Pages: 1-6
ISSN:1466-609X
DOI:10.1186/s13054-026-05947-5
Acceso en línea:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13054-026-05947-5
Enlace del recurso
Notas de Autor:Birte Arlt, Pietro Caironi, Jennifer Meessen, Oliver Hartmann, Alexandre Mebazaa, Matthieu Legrand, Etienne Gayat, Christian Nusshag, Thorsten Brenner, Pierre François Laterre, Ornella Tinelli, Roberto Latini nad Florian Uhle
Descripción
Sumario:Proenkephalin A 119-159 (penKid) is a functional kidney biomarker inversely correlating with the glomerular filtration rate. We conducted a patient-level meta-analysis to evaluate whether penKid provides additional value to serum creatinine (sCr) for assessing kidney function and outcome in patients with sepsis or septic shock.
Notas:Online veröffentlicht: 24. März 2026
Gesehen am 26.08.2026
Descripción Física:Online Resource
ISSN:1466-609X
DOI:10.1186/s13054-026-05947-5

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