Analysis of c-fos, c-jun, c-erbB1, c-erbB2 and c-myc in primary lung carcinomas and their lymph node metastases
The purpose of this study was to identify possible alterations in proto-oncogenes (c-fos, c-jun, c-erbB1, c-erbB2 and c-myc) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients. The analysis showed that proteins of c-jun and c-myc were expressed in...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 1994
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| In: |
Clinical & experimental metastasis
Year: 1994, Volume: 12, Issue: 4, Pages: 329-334 |
| ISSN: | 1573-7276 |
| DOI: | 10.1007/BF01753840 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF01753840
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| Author Notes: | Manfred Volm, Gerhard van Kaick and Jürgen Mattern |
| Summary: | The purpose of this study was to identify possible alterations in proto-oncogenes (c-fos, c-jun, c-erbB1, c-erbB2 and c-myc) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients. The analysis showed that proteins of c-jun and c-myc were expressed in a significantly higher frequency in metastases than in primary lung tumors. Gross differences were not found between primary tumors and metastatic tumors with regard to the expression of c-erbB1, c-erbB2 and c-fos. The finding of cases with a higher expression of c-jun and c-myc in lymph nodes suggests that metastatic capability may be higher in certain cell populations. |
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| Item Description: | Gesehen am 01.09.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1573-7276 |
| DOI: | 10.1007/BF01753840 |