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RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA...

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Autori principali: Tuorto, Francesca (Autore) , Liebers, Reinhard (Autore) , Musch, Tanja (Autore) , Schaefer, Matthias R. (Autore) , Hofmann, Sarah (Autore) , Kaiser, Stefanie (Autore) , Frye, Michaela (Autore) , Helm, Mark (Autore) , Stoecklin, Georg (Autore) , Lyko, Frank (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 12 August 2012
In: Nature structural & molecular biology
Year: 2012, Volume: 19, Fascicolo: 9, Pages: 900-905
ISSN:1545-9985
DOI:10.1038/nsmb.2357
Accesso online:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nsmb.2357
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nsmb.2357
Testo
Note sull'autore:Francesca Tuorto, Reinhard Liebers, Tanja Musch, Matthias Schaefer, Sarah Hofmann, Stefanie Kellner, Michaela Frye, Mark Helm, Georg Stoecklin & Frank Lyko
Descrizione
Riassunto:Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis.
Descrizione del documento:Gesehen am 01.09.2026
Descrizione fisica:Online Resource
ISSN:1545-9985
DOI:10.1038/nsmb.2357

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