RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Langue: | anglais |
| Publié: |
12 August 2012
|
| In: |
Nature structural & molecular biology
Year: 2012, Volume: 19, Numéro: 9, Pages: 900-905 |
| ISSN: | 1545-9985 |
| DOI: | 10.1038/nsmb.2357 |
| Accès en ligne: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nsmb.2357 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nsmb.2357 
|
| Notes sur l'auteur: | Francesca Tuorto, Reinhard Liebers, Tanja Musch, Matthias Schaefer, Sarah Hofmann, Stefanie Kellner, Michaela Frye, Mark Helm, Georg Stoecklin & Frank Lyko |
| Résumé: | Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis. |
|---|---|
| Description: | Gesehen am 01.09.2026 |
| Description matérielle: | Online Resource |
| ISSN: | 1545-9985 |
| DOI: | 10.1038/nsmb.2357 |