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Recent progress and future directions to advance glioblastoma research: a consensus perspective from the 2024 Christopher Davidson Forum

This position paper from the 2024 Christopher Davidson Forum held at WashU Medicine in Saint Louis provides a comprehensive consensus on scientific advances, key challenges, and future directions in glioblastoma (GBM) research. A multidisciplinary group of over 130 academic neuro-oncology profession...

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Autori principali: Dunn, Gavin P. (Autore) , Yu, Kenny K H (Autore) , Krucoff, Max O (Autore) , Bojanowski-Hoang, Kimberly (Autore) , Goldschmidt, Ezequiel (Autore) , Erol-Demirturk, Mariye (Autore) , Adesina, Daniel (Autore) , Quintana, Daniel (Autore) , Winkler, Frank (Autore) , Hervey-Jumper, Shawn (Autore) , Deneen, Benjamin (Autore) , Giles, David A (Autore) , Ko, Caroline H (Autore) , Leuthardt, Eric C (Autore) , Kim, Albert H (Autore) , Stegh, Alexander H (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: June 2026
In: Neuro-Oncology
Year: 2026, Volume: 28, Fascicolo: 6, Pages: 1366-1382
ISSN:1523-5866
DOI:10.1093/neuonc/noag043
Accesso online:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/neuonc/noag043
Testo
Note sull'autore:Gavin P Dunn, Kenny K H Yu, Max O Krucoff, Kimberly Bojanowski-Hoang, Ezequiel Goldschmidt, Mariye Erol-Demirturk, Daniel Adesina, Daniel Quintana, Frank Winkler, Shawn Hervey-Jumper, Benjamin Deneen, David A Giles, Caroline H Ko, Eric C Leuthardt, Albert H Kim, Alexander H Stegh, on behalf of the Christopher Davidson Forum investigators
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Riassunto:This position paper from the 2024 Christopher Davidson Forum held at WashU Medicine in Saint Louis provides a comprehensive consensus on scientific advances, key challenges, and future directions in glioblastoma (GBM) research. A multidisciplinary group of over 130 academic neuro-oncology professionals discussed recent developments and existing gaps in understanding the complex tumor biology of GBM tumors, characterizing and overcoming the resistance of GBM to immunotherapeutic approaches, defining tumor-brain interactions and their functional consequences for tumor progression and therapy resistance, and developing and clinically translating novel neuro- and nanotechnologies. We conclude with a call to action for researchers and clinicians in the neuro-oncology field to address fundamental gaps in our understanding of GBM tumor, immune, and neurobiology, and develop critical infrastructure to more rapidly translate novel therapeutic paradigms into the clinic through multi-disciplinary and cross-institutional collaborations.
Descrizione del documento:Online veröffentlicht: 23. März 2026
Gesehen am 02.09.2026
Descrizione fisica:Online Resource
ISSN:1523-5866
DOI:10.1093/neuonc/noag043

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